Isobe M, Huebner K, Maddon P J, Littman D R, Axel R, Croce C M
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4399-402. doi: 10.1073/pnas.83.12.4399.
The surface glycoproteins T4 and T8 define functionally distinct populations of T lymphocytes. We have obtained cDNA and genomic clones encoding the T4 molecule and used these as probes to determine the chromosomal location of this gene. Genomic blotting experiments, along with in situ hybridization analyses, indicate that the T4 gene resides on the short arm of human chromosome 12, at region p12-pter. Thus, the T4 gene is not linked to any known member of the immunoglobulin gene family, including its counterpart gene, T8, which resides on human chromosome 2 immediately distal to the immunoglobulin kappa locus.
表面糖蛋白T4和T8可定义功能不同的T淋巴细胞群体。我们已获得编码T4分子的cDNA和基因组克隆，并将其用作探针来确定该基因的染色体定位。基因组印迹实验以及原位杂交分析表明，T4基因位于人类第12号染色体的短臂上，位置为p12 - pter区域。因此，T4基因与免疫球蛋白基因家族的任何已知成员均无关联，包括其对应基因T8，T8位于人类第2号染色体上，紧邻免疫球蛋白κ基因座的远端。
