Qiu Yu, Ding Zhenzhen, Yang Deqin
Department of Endodontics, Stomatological Hospital of Chongqing Medical University; Chongqing Key Laboratory of Oral Diseases; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China.
Center for Neuroscience Research, Chongqing Medical University, Chongqing, China.
Int Dent J. 2025 Feb;75(1):363-374. doi: 10.1016/j.identj.2024.11.016. Epub 2024 Dec 12.
Macrophages are vital for regulating periodontal health, and numerous studies have extensively investigated their role in periodontitis progression. This study employs bibliometric analysis to identify research trends and hotspots related to macrophages in periodontitis from 2004 to 2024, thereby guiding future investigations and exploring potential clinical applications. Literature retrieval and dataset export were conducted via the Web of Science Core Collection database. Subsequently, bibliometric analysis was performed and the results were visualized using Microsoft Office Excel, VOSviewer, CiteSpace, and GraphPad Prism. A total of 1542 papers from 2004 to 2024 on the macrophages associated with periodontitis were identified. The annual number of publications and citations has steadily increased. China and the United States were the primary collaborators and drivers of research. Sichuan University had the largest number of published studies. The Journal of Periodontal Research published the most papers, while the Journal of Periodontology had the most citations. Daniel Grenier was the most prolific author and George Hajishengallis was the most frequently co-cited author. Co-citation analysis indicated that researchers primarily investigate the mechanisms of macrophages in periodontitis through both in vivo and in vitro experiments. Emerging research hotspots encompass keywords such as "macrophage polarization," "extracellular vesicles," and "regeneration." Research on macrophages in periodontitis is progressing quickly, and their strategic targeting offers a new and promising direction for future studies on regenerating periodontal tissues. The utilization of extracellular vesicles derived from diverse sources to regulate M1/M2 macrophage polarization presents a promising strategy for the treatment of periodontitis.
巨噬细胞对调节牙周健康至关重要，众多研究已广泛探究其在牙周炎进展中的作用。本研究采用文献计量分析来确定2004年至2024年期间与牙周炎中巨噬细胞相关的研究趋势和热点，从而指导未来的研究并探索潜在的临床应用。通过科学网核心合集数据库进行文献检索和数据集导出。随后，进行文献计量分析，并使用Microsoft Office Excel、VOSviewer、CiteSpace和GraphPad Prism对结果进行可视化。共确定了2004年至2024年期间1542篇关于与牙周炎相关巨噬细胞的论文。年度出版物数量和被引频次稳步增加。中国和美国是主要的合作方和研究驱动力。四川大学发表的研究数量最多。《牙周研究杂志》发表的论文数量最多，而《牙周病学杂志》的被引频次最高。丹尼尔·格雷尼尔是发文量最多的作者，乔治·哈吉桑加利斯是被共同引用频次最高的作者。共被引分析表明，研究人员主要通过体内和体外实验来研究巨噬细胞在牙周炎中的机制。新兴的研究热点包括“巨噬细胞极化”“细胞外囊泡”和“再生”等关键词。牙周炎中巨噬细胞的研究进展迅速，对其进行策略性靶向为未来牙周组织再生研究提供了一个新的且有前景的方向。利用来自不同来源的细胞外囊泡调节M1/M2巨噬细胞极化是治疗牙周炎的一种有前景的策略。
