Jain Kanika, Tyagi Tarun, Gu Sean X, Faustino E Vincent S, Hwa John
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Yale Cooperative Center of Excellence in Hematology, Yale School of Medicine, New Haven, CT, USA.
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Yale Cooperative Center of Excellence in Hematology, Yale School of Medicine, New Haven, CT, USA.
Trends Pharmacol Sci. 2025 Jan;46(1):78-93. doi: 10.1016/j.tips.2024.11.005. Epub 2024 Dec 12.
Recent studies have highlighted the complexity of platelet biology, revealing their diverse roles beyond hemostasis. Pathological platelet activation is now recognized as a key contributor to thrombosis and inflammation that are both central to cardiovascular disease (CVD). Emerging research emphasizes the significant impact of demographic factors - such as age, sex, race, and ethnicity - on CVD risk and responses to antiplatelet therapies. These population-based differences, shaped by genetic and non-genetic factors, highlight the need for reevaluation of antiplatelet strategies. We address current knowledge and emphasize the pressing need for further research into platelet biology and cardiovascular outcomes across diverse populations. In this review we advocate for tailored therapeutic approaches in CVD based on the recent demographic-focused findings.
近期研究凸显了血小板生物学的复杂性，揭示了其在止血之外的多种作用。病理性血小板活化现已被认为是血栓形成和炎症的关键促成因素，而这两者都是心血管疾病（CVD）的核心。新兴研究强调了年龄、性别、种族和民族等人口统计学因素对心血管疾病风险以及抗血小板治疗反应的重大影响。这些基于人群的差异，由遗传和非遗传因素塑造，凸显了重新评估抗血小板策略的必要性。我们阐述了当前的知识，并强调迫切需要针对不同人群进一步研究血小板生物学和心血管结局。在本综述中，我们基于近期以人口统计学为重点的研究结果，倡导针对心血管疾病采取个性化的治疗方法。
