van der Knaap-Kind L S, van der Kaaij N, Nijst S, Verhulst E, Koudstaal M, Wolvius E, Kragt L
Department of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Department of orthodontics, Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Eur Arch Paediatr Dent. 2025 Feb;26(1):131-137. doi: 10.1007/s40368-024-00980-w. Epub 2024 Dec 13.
This study aimed to determine the prevalence of hypomineralised second primary molars (HSPM) and molar incisor hypomineralisation (MIH) in cleft lip and/or palate (CL/P) patients.
A retrospective analysis of intraoral photographs of CL/P patients was done. All patients born between 2000 and 2011, and visiting the cleft team of the Erasmus Medical Center in Rotterdam, The Netherlands, were included. Their photos were scored on the presence and severity of HSPM and MIH using criteria formulated by the European Academy of Pediatric Dentistry. The outcomes were compared with data of the general population, extracted from the Generation R study.
The photos of 535 CL/P patients were evaluated. The overall prevalence of HSPM in CL/P patients was 15.2%, of MIH 12.8%. HSPM and MIH prevalence was significantly higher (both p < 0.001) compared to prevalence in the general population. No significant differences were found in prevalence of HSPM nor of MIH in CL/P patients based on gender (p = 0.891 resp. p = 0.405), cleft type (p = 0.282, resp. p = 0.415), Pierre Robin (p = 0.837, resp. p = 0.169) or other comorbidities (p = 0.553, resp. p = 0.617). CL/P patients with HSPM were almost 3 times more likely diagnosed with MIH than CL/P patients without HSPM (OR = 2.57, p = 0.002).
The prevalence of HSPM and MIH is higher in patients with CL/P than in the general population.
本研究旨在确定唇腭裂（CL/P）患者中矿化不足的第二乳磨牙（HSPM）和磨牙切牙矿化不全（MIH）的患病率。
对CL/P患者的口腔内照片进行回顾性分析。纳入所有在2000年至2011年之间出生且前往荷兰鹿特丹伊拉斯姆斯医学中心腭裂团队就诊的患者。根据欧洲儿童牙科学会制定的标准，对他们的照片进行HSPM和MIH的存在情况及严重程度评分。将结果与从Generation R研究中提取的普通人群数据进行比较。
对535例CL/P患者的照片进行了评估。CL/P患者中HSPM的总体患病率为15.2%，MIH为12.8%。与普通人群的患病率相比，HSPM和MIH的患病率显著更高（两者p均<0.001）。基于性别（p = 0.891和p = 0.405）、腭裂类型（p = 0.282和p = 0.415）、Pierre Robin综合征（p = 0.837和p = 0.169）或其他合并症（p = 0.553和p = 0.617），CL/P患者中HSPM和MIH的患病率未发现显著差异。患有HSPM的CL/P患者被诊断为MIH的可能性几乎是没有HSPM的CL/P患者的3倍（OR = 2.57，p = 0.002）。
CL/P患者中HSPM和MIH的患病率高于普通人群。
