de Farias Aline Leite, Rojas-Gualdrón Diego Fernando, Restrepo Manuel, Zecchin Karina Gottardello, Bussaneli Diego Girotto, Yupanqui Kasandra, Raposo-Amaral Cassio Eduardo, Santos-Pinto Lourdes
Basic and Clinical Research Group in Dentistry, School of Dentistry, CES University, Medellín, Colombia.
Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), Araraquara School of Dentistry, Araraquara, São Paulo, Brazil.
Clin Oral Investig. 2025 Apr 25;29(5):269. doi: 10.1007/s00784-025-06311-7.
To identify and characterize hypomineralization in the second primary molar (HSPM) and molar incisor hypomineralization (MIH), as well as other developmental defects of enamel (DDE) in patients with clefts considering dentition type, tooth type, phenotype and cleft laterality.
In this cross-sectional retrospective study, 6432 deciduous and permanent teeth of 290 patients with clefts aged between 3 and 14 years in a referral hospital were assessed using intraoral photographs. The classification of demarcated hypomineralization was carried out by a calibrated examiner using the MIH index. Statistical analyses were performed using a binomial generalized linear model.
Deciduous and permanent molars were the most affected by HSPM and MIH, whereas incisors and canines were most affected by hypoplasia, with the upper arch being most affected by DDE. Cleft phenotypes involving the palate were associated with HSPM (OR = 31; 95% CI: 1.0-59.3) and MIH (OR = 31.6; 95% CI: 0.6-53.2).
Patients with clefts had a high prevalence of HSPM and MIH in the upper arch and were associated with more severe cleft phenotypes.
Pediatric dentists who are members of the multidisciplinary teams responsible for caring for patients with clefts need to have a more discerning clinical eye when diagnosing DDE in patients with clefts. Posterior teeth are more susceptible to demarcated hypomineralizations in patients with clefts, while anterior teeth are more susceptible to hypoplasias.
根据牙列类型、牙齿类型、表型和腭裂侧别，识别和描述双侧乳磨牙矿化不全（HSPM）、磨牙切牙矿化不全（MIH）以及腭裂患者其他牙釉质发育缺陷（DDE）。
在这项横断面回顾性研究中，使用口腔内照片对一家转诊医院中290例年龄在3至14岁的腭裂患者的6432颗乳牙和恒牙进行了评估。由一名经过校准的检查者使用MIH指数对划定的矿化不全进行分类。使用二项式广义线性模型进行统计分析。
乳牙和恒牙磨牙受HSPM和MIH影响最大，而切牙和尖牙受发育不全影响最大，上牙弓受DDE影响最大。涉及腭部的腭裂表型与HSPM（比值比[OR]=31；95%置信区间[CI]：1.0 - 59.3）和MIH（OR = 31.6；95% CI：0.6 - 53.2）相关。
腭裂患者上牙弓中HSPM和MIH的患病率较高，且与更严重的腭裂表型相关。
负责照顾腭裂患者的多学科团队中的儿科牙医在诊断腭裂患者的DDE时需要有更敏锐的临床眼光。腭裂患者的后牙更容易出现划定的矿化不全，而前牙更容易出现发育不全。
