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Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis.

作者信息

Ma Guixing, Han Yingying, Tang Wanze, Zhou Bo, Chen Litong, Ding Zhen, Cheng Siyuan, Chen Di, Cao Huiling

机构信息

Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Key University Laboratory of Metabolism and Health of Guangdong, Southern University of Science and Technology, Shenzhen 518055, China.

Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

出版信息

Protein Cell. 2025 Jun 20;16(6):497-502. doi: 10.1093/procel/pwae066.

DOI:10.1093/procel/pwae066
PMID:39673404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12187329/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f2/12187329/542277cd2396/pwae066_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f2/12187329/feefa5f39458/pwae066_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f2/12187329/542277cd2396/pwae066_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f2/12187329/feefa5f39458/pwae066_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5f2/12187329/542277cd2396/pwae066_fig2.jpg

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本文引用的文献

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Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models.重新评估小鼠骨髓中的内皮到间充质转化：谱系追踪模型的见解。
Nat Commun. 2023 Dec 20;14(1):8461. doi: 10.1038/s41467-023-44312-w.
2
Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPAR/FABP4 signaling in mice.在小鼠中，靶向脂肪细胞中的Kindlin-2通过抑制FAS/PPAR/FABP4信号通路增加骨量。
Acta Pharm Sin B. 2023 Nov;13(11):4535-4552. doi: 10.1016/j.apsb.2023.07.001. Epub 2023 Jul 7.
3
The role of E3 ubiquitin ligases in bone homeostasis and related diseases.
E3泛素连接酶在骨稳态及相关疾病中的作用。
Acta Pharm Sin B. 2023 Oct;13(10):3963-3987. doi: 10.1016/j.apsb.2023.06.016. Epub 2023 Jul 6.
4
Kindlin-2 controls angiogenesis through modulating Notch1 signaling.Kindlin-2 通过调节 Notch1 信号通路控制血管生成。
Cell Mol Life Sci. 2023 Jul 22;80(8):223. doi: 10.1007/s00018-023-04866-w.
5
Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation.内皮细胞衍生的基质细胞有助于造血骨髓龛的形成。
Cell Stem Cell. 2021 Apr 1;28(4):653-670.e11. doi: 10.1016/j.stem.2021.01.006. Epub 2021 Feb 8.
6
Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice.Kindlin-2 通过调节小鼠中的 PTH1R 来调节骨骼内稳态。
Signal Transduct Target Ther. 2020 Dec 26;5(1):297. doi: 10.1038/s41392-020-00328-y.
7
Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer.内皮细胞向成骨细胞的转变引发前列腺癌的成骨细胞转移。
Dev Cell. 2017 Jun 5;41(5):467-480.e3. doi: 10.1016/j.devcel.2017.05.005.
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Genetic analysis of Runx2 function during intramembranous ossification.膜内成骨过程中Runx2功能的遗传分析。
Development. 2016 Jan 15;143(2):211-8. doi: 10.1242/dev.128793. Epub 2015 Dec 10.
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Chemical activation of the mechanotransduction channel Piezo1.机械转导通道Piezo1的化学激活
Elife. 2015 May 22;4:e07369. doi: 10.7554/eLife.07369.
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Nature. 2014 Nov 13;515(7526):279-282. doi: 10.1038/nature13701. Epub 2014 Aug 10.