Su Shan, Tian Limin
The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Department of Endocrinology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610000, China.
Calcif Tissue Int. 2024 Dec 14;116(1):6. doi: 10.1007/s00223-024-01329-7.
The relationship between dietary tryptophan intake and the risk of low bone mineral density (LBMD) has not been thoroughly evaluated. This study aimed to examine the relationship between dietary tryptophan intake and LBMD. A total of 12,003 participants aged 50 years and older with complete data on bone mineral density (BMD) and tryptophan intake from the National Health and Nutrition Examination Survey (NHANES) 2005 to 2020 were included in this cross-sectional study. The median dietary tryptophan intake among the 12,003 participants was 1822.14 mg/day, with significantly lower levels observed in individuals with LBMD compared to those with normal bone mass (1740.45 mg/day vs. 2041.39 mg/day, p < 0.001). For every 2.7-fold increase in dietary tryptophan intake, the risk of low BMD decreases by 22%. When dietary tryptophan intake was categorized into quartiles, significantly lower risks of LBMD were observed in the third [Odds Ratio (OR) = 0.68, 95% confidence interval (CI): 0.51-0.91] and fourth (OR = 0.65, 95% CI: 0.49-0.87) quartiles compared to the reference group after multivariable adjustment. Moreover, the restricted cubic spline (RCS) results revealed a negative nonlinear relationship between dietary tryptophan intake and LBMD (p for overall < 0.001, p for nonlinear < 0.05), with this correlation remaining consistent across various population subgroups and exhibiting no significant interaction according to stratification variables. Sensitivity analyses further substantiated these findings. Overall, we found that increased dietary tryptophan intake may be associated with a lower risk of LBMD among individuals aged ≥ 50 years, highlighting the importance of optimizing tryptophan nutrition for reducing osteoporosis risk.
膳食色氨酸摄入量与低骨密度（LBMD）风险之间的关系尚未得到充分评估。本研究旨在探讨膳食色氨酸摄入量与LBMD之间的关系。本横断面研究纳入了2005年至2020年美国国家健康与营养检查调查（NHANES）中12003名50岁及以上、有骨密度（BMD）和色氨酸摄入量完整数据的参与者。12003名参与者的膳食色氨酸摄入量中位数为1822.14毫克/天，与骨量正常者相比，LBMD个体的色氨酸摄入量显著较低（1740.45毫克/天对2041.39毫克/天，p＜0.001）。膳食色氨酸摄入量每增加2.7倍，低BMD风险降低22%。当将膳食色氨酸摄入量分为四分位数时，多变量调整后，与参照组相比，第三四分位数[比值比（OR）=0.68，95%置信区间（CI）：0.51-0.91]和第四四分位数（OR=0.65，95%CI：0.49-0.87）的LBMD风险显著较低。此外，受限立方样条（RCS）结果显示膳食色氨酸摄入量与LBMD之间呈负非线性关系（总体p＜0.001，非线性p＜0.05），这种相关性在各人群亚组中保持一致，且根据分层变量未显示出显著交互作用。敏感性分析进一步证实了这些发现。总体而言，我们发现膳食色氨酸摄入量增加可能与≥50岁个体的LBMD风险较低有关，这突出了优化色氨酸营养对降低骨质疏松症风险的重要性。
