Ghasempour Dabaghi Ghazal, Pourmoghaddas Ali, Rabiee Rad Mehrdad, Zarepur Ehsan, Mohammadifard Noushin, Azdaki Nahid, Salehi Nahid, Solati Kamal, Ghaffari Samad, Salari Arsalan, Assareh Ahmadreza, Shabani Niloufar, Sarrafzadegan Nizal
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Arch Gynecol Obstet. 2025 Jan;311(1):135-143. doi: 10.1007/s00404-024-07860-0. Epub 2024 Dec 14.
Premature coronary artery diseases (PCAD) is a major health concern. Finding the potential risk factors for this health issue is crucial for early detection and prevention. This study aimed to evaluate the relation between age at menarche and PCAD presence and severity.
This study was performed in the framework of the Iran premature coronary disease (IPAD). IPAD is a multiethnic case-control study conducted from 2020. PCAD was defined as at least 75% obstruction in more than one coronary artery or above 50% in the left main artery in man and women under the age of 60 years and 70 years, respectively. Age at menarche is evaluate using self-reporting questionnaire. We categorized age at menarche into three groups: early (8-11 years), average (12-13 years), and late (14-17 years).
A total number of 1035 women participated in this study. No significant association was observed between every year increase in age at menarche and the PCAD risk after fully adjustment with odds ratio (OR) 95% confidence interval (95% CI) OR = 0.98, 95% CI 0.91-1.05, P = 0.65 Besides, no significant association was seen between number of obstructed vessels and age at menarche (OR = 1.01; 95% CI 0.94-1.08, P = 0.76). Following the subgroup analysis based on ethnicity, it was observed that only individuals of Gilak ethnicity showed a significant association between a 1-year increase in age at menarche and the risk of PCAD (OR = 0.68, 95% CI 0.49-0.95, P = 0.026).
This study suggested that age at menarche may not be connected to PCAD risk and number of obstructed vessels. However, ethnicity may have roles in terms of the relationship between age at menarche and PCAD. More longitudinal studies are needed to evaluate this relationship.
IR.MUI.REC.1396.2.055.
早发性冠状动脉疾病（PCAD）是一个主要的健康问题。找出这一健康问题的潜在风险因素对于早期发现和预防至关重要。本研究旨在评估初潮年龄与PCAD的存在及严重程度之间的关系。
本研究在伊朗早发性冠状动脉疾病（IPAD）框架内进行。IPAD是一项自2020年开始的多民族病例对照研究。PCAD在60岁以下男性和70岁以下女性中分别定义为一条以上冠状动脉至少75%阻塞或左主干动脉50%以上阻塞。初潮年龄通过自我报告问卷进行评估。我们将初潮年龄分为三组：早（8 - 11岁）、平均（12 - 13岁）和晚（14 - 17岁）。
共有1035名女性参与本研究。在完全调整后，初潮年龄每增加一岁与PCAD风险之间未观察到显著关联，优势比（OR）95%置信区间（95%CI）为OR = 0.98，95%CI为0.91 - 1.05，P = 0.65。此外，阻塞血管数量与初潮年龄之间也未观察到显著关联（OR = 1.01；95%CI为0.94 - 1.08，P = 0.76）。在基于种族的亚组分析之后，观察到只有吉拉克族个体显示初潮年龄每增加一岁与PCAD风险之间存在显著关联（OR = 0.68，95%CI为0.49 - 0.95，P = 0.026）。
本研究表明初潮年龄可能与PCAD风险及阻塞血管数量无关。然而，种族在初潮年龄与PCAD的关系方面可能起作用。需要更多的纵向研究来评估这种关系。
IR.MUI.REC.1396.2.055。
