Zhang Bin, Chen Su-Lan, Teng Xin, Han Qi, Wu Tong, Yang Zhen, Liu Yin, Xiang Ke, Sun Li
Changchun University of Chinese Medicine, Changchun, Jilin Province, 130017, China.
Department of Geriatrics, Jilin Provincial Academy of Traditional Chinese Medicine, No.6426 of Freie Road, Changchun, Jilin Province, 130021, China.
Neurochem Res. 2024 Dec 14;50(1):59. doi: 10.1007/s11064-024-04314-6.
Brain-derived neurotrophic factor (BDNF) is essential for the development and functioning of the vestibular system. BDNF promotes the growth, differentiation, and synaptic plasticity of vestibular neurons, ensuring their normal operation and maintenance. According to research, BDNF is pivotal during vestibular compensation, aiding in the recovery of neuron function by remodeling the spontaneous resting potentials of damaged vestibular neurons. Additionally, BDNF exhibits dose-dependent and age-dependent characteristics during vestibular system development, with its deficiencies leading to the degeneration of vestibular neurons. BDNF dynamically interacts with other neurotrophic factors, such as fibroblast growth factor-2 (FGF-2) and glial cell line-derived neurotrophic factor (GDNF), synergistically enhancing neuron survival and functionality. This review outline the function of BDNF in the vestibulocochlear system and explores its potential therapeutic applications, offering fresh perspectives and guidance for future research and treatment of vestibulocochlear system disorders.
脑源性神经营养因子（BDNF）对于前庭系统的发育和功能至关重要。BDNF促进前庭神经元的生长、分化和突触可塑性，确保其正常运作和维持。根据研究，BDNF在前庭代偿过程中起关键作用，通过重塑受损前庭神经元的自发静息电位来帮助恢复神经元功能。此外，BDNF在前庭系统发育过程中表现出剂量依赖性和年龄依赖性特征，其缺乏会导致前庭神经元退化。BDNF与其他神经营养因子，如成纤维细胞生长因子-2（FGF-2）和胶质细胞源性神经营养因子（GDNF）动态相互作用，协同增强神经元存活和功能。本综述概述了BDNF在前庭蜗系统中的功能，并探讨了其潜在的治疗应用，为未来前庭蜗系统疾病的研究和治疗提供了新的视角和指导。
