Cheng Xiaoxiao, Yang Jie, Wang Zhijie, Zhou Kefan, An Xuejiao, Xu Zhenjiang Zech, Lu Hui
Jiangxi Agricultural University, College of Bioscience and Bioengineering, Nanchang, PR China.
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, PR China.
Life Sci. 2025 Jan 15;361:123309. doi: 10.1016/j.lfs.2024.123309. Epub 2024 Dec 12.
The gut microbiome affects the occurrence and development of metabolic diseases, with a significant amount of research focused on intestinal bacteria. As an important part of the gut microbiome, gut viruses were studied recently, particularly through fecal virome transplantation (FVT), revealing manipulating the gut virus could reverse overweight and glucose intolerance in mice. And human cohort studies found gut virome changed significantly in patients with metabolic disease. By summarizing those studies, we compared the research and analytical methods, as well as the similarities and differences in their results, and analyzed the reasons for these discrepancies. FVT provided potential value to improve metabolic diseases, but the mechanisms involved and the effect of FVT on humans should be investigated further. The potential methods of regulating intestinal virome composition and the possible mechanisms of intestinal virome changes affecting metabolic diseases were also discussed.
肠道微生物群会影响代谢性疾病的发生和发展，大量研究聚焦于肠道细菌。作为肠道微生物群的重要组成部分，肠道病毒最近受到了研究，特别是通过粪便病毒组移植（FVT），结果显示操控肠道病毒可以逆转小鼠的超重和葡萄糖不耐受。而且人类队列研究发现，代谢性疾病患者的肠道病毒组发生了显著变化。通过总结这些研究，我们比较了研究和分析方法及其结果的异同，并分析了产生这些差异的原因。FVT为改善代谢性疾病提供了潜在价值，但其中涉及的机制以及FVT对人类的影响仍有待进一步研究。我们还讨论了调节肠道病毒组组成的潜在方法以及肠道病毒组变化影响代谢性疾病的可能机制。
