Deng Rui, Zong Gang-Fan, Wang Xi, Yue Bing-Jie, Cheng Peng, Tao Rui-Zhi, Li Xiaoman, Wei Zhong-Hong, Lu Yin
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023. China; Nanjing Integrated Traditional Chinese And Western Medicine Hospital, Nanjing 210018. China.
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023. China; Jiangsu Joint International Research Laboratory of Chinese Medicine and Regenerative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Biochim Biophys Acta Rev Cancer. 2025 Feb;1880(1):189241. doi: 10.1016/j.bbcan.2024.189241. Epub 2024 Dec 12.
Cancer represents a substantial threat to human health and mortality, necessitating the development of novel pharmacological agents with innovative mechanisms of action. Consequently, extensive research has been directed toward discovering new anticancer compounds derived from natural sources, including plants, microbes, and marine organisms. This review offers a comprehensive analysis of natural anticancer agents that are either currently undergoing clinical trials or have been integrated into clinical practice. A comprehensive understanding of the historical origins of natural anticancer agents, alongside traditional targets for tumor treatment and the distinct characteristics of cancer, can significantly facilitate researchers in the discovery and development of innovative anticancer drugs for clinical use. Furthermore, the exploration of microbial and marine sources is currently a prominent area of focus in the clinical application and advancement of new anticancer therapies. Detailed classification and elucidation of the functions and antitumor properties of these natural products are essential. It is imperative to comprehensively summarize and comprehend the natural anticancer drugs that have been and continue to be utilized in clinical settings.
癌症对人类健康和死亡率构成重大威胁，因此需要开发具有创新作用机制的新型药物。因此，广泛的研究致力于发现源自天然来源（包括植物、微生物和海洋生物）的新型抗癌化合物。本综述对目前正在进行临床试验或已纳入临床实践的天然抗癌药物进行了全面分析。全面了解天然抗癌药物的历史起源、传统肿瘤治疗靶点以及癌症的独特特征，可显著促进研究人员发现和开发用于临床的创新抗癌药物。此外，微生物和海洋来源的探索目前是新抗癌疗法临床应用和进展的一个突出重点领域。对这些天然产物的功能和抗肿瘤特性进行详细分类和阐释至关重要。必须全面总结和理解已在临床环境中使用并将继续使用的天然抗癌药物。
