Yang Hui, Xiang Yuanyuan, Wang Jiaxuan, Ke Zunliang, Zhou Weixin, Yin Xiaoping, Zhang Manqing, Chen Zhiying
Department of Neurology, Clinical Medical School of Jiujiang University, Jiujiang, Jiangxi 332000, China; Jiujiang Clinical Precision Medicine Research Center, Jiujiang, Jiangxi 332000, China; School of Basic Medicine, Jiujiang University, Jiujiang, Jiangxi 332000, China.
Department of Neurology, Clinical Medical School of Jiujiang University, Jiujiang, Jiangxi 332000, China.
Int J Biol Macromol. 2025 Feb;288:138747. doi: 10.1016/j.ijbiomac.2024.138747. Epub 2024 Dec 12.
Secreted protein acidic and rich in cysteine (SPARC), an essential stromal cell protein, plays a crucial role in angiogenesis and maintaining endothelial barrier function. This protein is expressed by diverse cell types, including endothelial cells, fibroblasts, and macrophages, with increased expression found in regions of tissues undergoing active remodeling, repair, and proliferation. The role of SPARC in non-neural tissues is of significant interest. In the central nervous system (CNS), SPARC is highly expressed in blood vessels during early development. It becomes down-regulated as the brain matures, a pattern consistent with its role in angiogenesis and blood-brain barrier (BBB) establishment. In this review, we explore the multifaceted roles of SPARC in regulating CNS disorders, particularly its action in angiogenesis, inflammatory responses, neural system development and repair, barrier establishment, maintenance of BBB function, and the pathogenesis of CNS disorders triggered by BBB dysfunction.
富含半胱氨酸的酸性分泌蛋白（SPARC）是一种重要的基质细胞蛋白，在血管生成和维持内皮屏障功能中起关键作用。这种蛋白由多种细胞类型表达，包括内皮细胞、成纤维细胞和巨噬细胞，在经历活跃重塑、修复和增殖的组织区域中表达增加。SPARC在非神经组织中的作用备受关注。在中枢神经系统（CNS）中，SPARC在早期发育过程中在血管中高度表达。随着大脑成熟，它会下调，这种模式与其在血管生成和血脑屏障（BBB）形成中的作用一致。在这篇综述中，我们探讨了SPARC在调节中枢神经系统疾病中的多方面作用，特别是其在血管生成、炎症反应、神经系统发育和修复、屏障形成、血脑屏障功能维持以及由血脑屏障功能障碍引发的中枢神经系统疾病发病机制中的作用。
