Department of Neurology, the First Affiliated Hospital of Hainan Medical University, Haikou, China; Key Laboratory of Brain Science Research & Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, China.
Department of psychology, the First Affiliated Hospital of Hainan Medical University, Haikou, China.
Brain Res Bull. 2020 Oct;163:178-189. doi: 10.1016/j.brainresbull.2020.05.005. Epub 2020 May 14.
SPARC (secreted protein acidic and rich in cysteine) family of proteins is a class of protein involved in tissue development and repair by regulating cell adhesion, proliferation, metastasis, and growth factor signaling to affect the extracellular matrix (ECM) and interactions between cells. Although being highly valued in non-nerve tissues, studies in both cell and animal models have been revealed that SPARC family proteins may also continue to play a vital role in central nervous system (CNS) diseases and development. These SPARC family proteins are widely expressed in the CNS of normal people, and significantly increased in brain tissue following disease or injury, such as SPARC, SPARCL-1, FSTL-1 and testican. In our review, we will pay attention to the functions of SPARC family proteins in autophagy, apoptosis, angiogenesis, adipogenesis, inflammatory response, and cerebral tissue development, injury and repair mainly including but not limited to axon regeneration, formation of glial scar, neural plasticity, regulation of nerve conduction related receptors and rewiring of neural circuitry.
富含半胱氨酸和酸性分泌蛋白（secreted protein acidic and rich in cysteine，SPARC）家族蛋白是一类参与组织发育和修复的蛋白，通过调节细胞黏附、增殖、转移和生长因子信号来影响细胞外基质（extracellular matrix，ECM）和细胞间的相互作用。尽管在非神经组织中具有重要价值，但在细胞和动物模型中的研究表明，SPARC 家族蛋白也可能继续在中枢神经系统（central nervous system，CNS）疾病和发育中发挥重要作用。这些 SPARC 家族蛋白在正常人的中枢神经系统中广泛表达，在疾病或损伤后，如 SPARC、SPARCL-1、FSTL-1 和 testican，脑组织中的表达显著增加。在我们的综述中，我们将关注 SPARC 家族蛋白在自噬、细胞凋亡、血管生成、脂肪生成、炎症反应和脑组织发育、损伤和修复中的作用，主要包括但不限于轴突再生、神经胶质瘢痕形成、神经可塑性、调节与神经传导相关的受体以及神经回路的重新布线。
