Gray H H, Poston L, Johnson V E, Hilton P J
Clin Sci (Lond). 1985 Feb;68(2):239-41. doi: 10.1042/cs0680239.
Sodium efflux rate constants and intracellular sodium were measured in leucocytes from healthy volunteers in the presence and absence of the calcium antagonist verapamil hydrochloride. Verapamil stimulated sodium pump activity and this effect was dependent on the presence of external calcium. Verapamil has been reported to reverse the abnormality of sodium transport seen in leucocytes from patients with essential hypertension and the present study demonstrates that sodium pump activity in leucocytes from control subjects is also stimulated by exposure to verapamil in vitro. This direct cellular effect appears to be due to the calcium antagonist properties of the drug.
在有和没有钙拮抗剂盐酸维拉帕米的情况下，测量了健康志愿者白细胞中的钠流出速率常数和细胞内钠含量。维拉帕米刺激钠泵活性，且这种作用依赖于细胞外钙的存在。据报道，维拉帕米可逆转原发性高血压患者白细胞中出现的钠转运异常，本研究表明，在体外暴露于维拉帕米时，对照受试者白细胞中的钠泵活性也会受到刺激。这种直接的细胞效应似乎归因于该药物的钙拮抗特性。
