Forrester T E, Alleyne G A
Br Med J (Clin Res Ed). 1981 Jul 4;283(6283):5-7. doi: 10.1136/bmj.283.6283.5.
Leucocyte sodium and potassium content and concentrations were measured along with ouabain-sensitive and ouabain-insensitive rate constants for sodium efflux in 14 controls and 20 black patients with essential hypertension. Leucocyte sodium content was significantly increased in the patients (mean 101.1 +/- 7.8 mmol/kg dry solids v 74.5 +/- 7.6 mmol/kg dry solids; p less than 0.05), whereas the rate constants for sodium efflux were not significantly reduced. There was no difference between the two groups in cell potassium values. The increase in leucocyte sodium content in the presence of normal rate constants for sodium efflux suggests an increase in membrane permeability to sodium, which might be important in the pathogenesis of essential hypertension.
对14名对照者和20名原发性高血压黑人患者的白细胞钠、钾含量及浓度，以及钠外流的哇巴因敏感和哇巴因不敏感速率常数进行了测量。患者的白细胞钠含量显著增加（平均101.1±7.8 mmol/kg干物质，而对照组为74.5±7.6 mmol/kg干物质；p<0.05），而钠外流的速率常数没有显著降低。两组的细胞钾值没有差异。在钠外流速率常数正常的情况下白细胞钠含量增加，提示钠的膜通透性增加，这可能在原发性高血压的发病机制中起重要作用。
