牙买加高血压患者白细胞中钠、钾及钠外流速率常数
Sodium, potassium, and rate constants for sodium efflux in leucocytes from hypertensive Jamaicans.
作者信息
Forrester T E, Alleyne G A
出版信息
Br Med J (Clin Res Ed). 1981 Jul 4;283(6283):5-7. doi: 10.1136/bmj.283.6283.5.
Abstract
Leucocyte sodium and potassium content and concentrations were measured along with ouabain-sensitive and ouabain-insensitive rate constants for sodium efflux in 14 controls and 20 black patients with essential hypertension. Leucocyte sodium content was significantly increased in the patients (mean 101.1 +/- 7.8 mmol/kg dry solids v 74.5 +/- 7.6 mmol/kg dry solids; p less than 0.05), whereas the rate constants for sodium efflux were not significantly reduced. There was no difference between the two groups in cell potassium values. The increase in leucocyte sodium content in the presence of normal rate constants for sodium efflux suggests an increase in membrane permeability to sodium, which might be important in the pathogenesis of essential hypertension.
摘要
对14名对照者和20名原发性高血压黑人患者的白细胞钠、钾含量及浓度，以及钠外流的哇巴因敏感和哇巴因不敏感速率常数进行了测量。患者的白细胞钠含量显著增加（平均101.1±7.8 mmol/kg干物质，而对照组为74.5±7.6 mmol/kg干物质；p<0.05），而钠外流的速率常数没有显著降低。两组的细胞钾值没有差异。在钠外流速率常数正常的情况下白细胞钠含量增加，提示钠的膜通透性增加，这可能在原发性高血压的发病机制中起重要作用。
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本文引用的文献
1
Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension.长期过量摄入盐分的影响。有证据表明遗传因素在实验性高血压易感性中起重要作用。
J Exp Med. 1962 Jun 1;115(6):1173-90. doi: 10.1084/jem.115.6.1173.
2
Evidence for relationship between sodium (chloride) intake and human essential hypertension.钠（氯）摄入量与人类原发性高血压之间关系的证据。
AMA Arch Intern Med. 1954 Oct;94(4):525-31. doi: 10.1001/archinte.1954.00250040017003.
3
Increased sodium-lithium countertransport in red cells of patients with essential hypertension.原发性高血压患者红细胞中钠-锂逆向转运增加。
N Engl J Med. 1980 Apr 3;302(14):772-6. doi: 10.1056/NEJM198004033021403.
4
Intracellular concentrations of water and of the principal electrolytes determined by analysis of isolated human leucocytes.
Clin Sci. 1969 Aug;37(1):205-19.
5
How sodium and the kidney relate to the hypertensive arteriole.
Fed Proc. 1974 Feb;33(2):138-42.
6
Hypertension as a disease of modern society.高血压作为一种现代社会的疾病。
Int J Health Serv. 1975;5(4):539-58. doi: 10.2190/UT72-3RTX-V0KN-64AF.
7
Characterization of sodium-transport disorders in disease: different effects upon sodium and potassium of changes in the sodium pump and in membrane permeability.疾病中钠转运紊乱的特征：钠泵和膜通透性变化对钠和钾的不同影响。
Clin Sci (Lond). 1979 Oct;57(4):289-93. doi: 10.1042/cs0570289.
8
Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis.
Am J Physiol. 1977 May;232(5):C165-73. doi: 10.1152/ajpcell.1977.232.5.C165.
9
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