Yang Yanru, Fan Linni, Li Mingyang, Wang Zhe
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, China.
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Semin Cancer Biol. 2025 Jan;108:71-82. doi: 10.1016/j.semcancer.2024.12.001. Epub 2024 Dec 13.
With the rapid development of immunological techniques in recent years, our understanding of immune senescence has gradually deepened, but the role of immune senescence in cancer biology remains incompletely elucidated. Understanding these mechanisms and interactions is crucial for the development of tumor biology. This review examines five key areas: the classification and main features of immune senescence, factors influencing immune cell senescence in cancer, the reciprocal causal cycle between immune senescence and malignancy, and the potential of immune senescence as a target for cancer immunotherapy.
近年来，随着免疫技术的迅速发展，我们对免疫衰老的理解逐渐加深，但免疫衰老在癌症生物学中的作用仍未完全阐明。了解这些机制及其相互作用对于肿瘤生物学的发展至关重要。本文综述了五个关键领域：免疫衰老的分类和主要特征、癌症中影响免疫细胞衰老的因素、免疫衰老与恶性肿瘤之间的相互因果循环，以及免疫衰老作为癌症免疫治疗靶点的潜力。
