Gao Minling, Li Haiou, Zhang Jinfang
Department of Hepatobiliary and Pancreatic Surgery, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Key Laboratory of Tumor Biological Behavior/Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Semin Cancer Biol. 2025 Feb;109:1-7. doi: 10.1016/j.semcancer.2024.11.004. Epub 2024 Dec 13.
The Retinoblastoma (RB) protein is crucial for regulating gene transcription and chromatin remodeling, impacting cell cycle progression, cellular senescence, and tumorigenesis. Cellular senescence, characterized by irreversible growth arrest and phenotypic alterations, serves as a vital barrier against tumor progression and age-related diseases. RB is crucial in mediating senescence and tumor suppression by modulating the RB-E2F pathway and cross talking with other key senescence effectors such as p53 and p16. The interplay between RB-mediated cell cycle arrest and cellular senescence offers critical insights into tumorigenesis and potential therapeutic strategies. Leveraging RB-mediated senescence presents promising opportunities for cancer therapy, including novel approaches in tumor immunotherapy designed to enhance treatment efficacy. This review highlights recent advancements in the RB signaling pathway, focusing on its roles in cellular senescence and tumor suppression, and discusses its potential to improve tumor management and clinical outcomes.
视网膜母细胞瘤（RB）蛋白对于调节基因转录和染色质重塑至关重要，影响细胞周期进程、细胞衰老和肿瘤发生。细胞衰老以不可逆的生长停滞和表型改变为特征，是对抗肿瘤进展和与年龄相关疾病的重要屏障。RB通过调节RB-E2F通路并与其他关键衰老效应因子（如p53和p16）相互作用，在介导衰老和肿瘤抑制中起关键作用。RB介导的细胞周期停滞与细胞衰老之间的相互作用为肿瘤发生和潜在治疗策略提供了重要见解。利用RB介导的衰老为癌症治疗带来了有前景的机会，包括旨在提高治疗效果的肿瘤免疫治疗新方法。本综述重点介绍了RB信号通路的最新进展，聚焦于其在细胞衰老和肿瘤抑制中的作用，并讨论了其改善肿瘤管理和临床结果的潜力。
