特发性帕金森病的非运动症状及其与疾病严重程度和病程的相关性：一项横断面研究。

Nonmotor Manifestations of Idiopathic Parkinson's Disease and Its Correlation with the Severity and Duration of the Disease: A Cross-sectional Study.

作者信息

Vijay Mangalapalli, Velayutham Saravanan Sakthi, Reddy Pedda Gangula Pavan Kumar, Mugundhan Krishnan

机构信息

Resident, Department of Neurology, Stanley Medical College, Chennai, Tamil Nadu, India, Corresponding Author.

Assistant Professor, Department of Neurology, Stanley Medical College, Chennai, Tamil Nadu, India.

出版信息

J Assoc Physicians India. 2024 Dec;72(12):e26-e29. doi: 10.59556/japi.72.0717.

DOI:10.59556/japi.72.0717

PMID:39676193

Abstract

OVERVIEW

Parkinson's disease (PD) is a neurodegenerative disorder that is common in individuals over the age of 50 years, affecting about 1% of the population. Nonmotor symptoms (NMS) are a common occurrence in PD, but they are often ignored by motor symptoms. Studies have shown that NMS in PD show a significant impact on quality of life. The introduction of tools like nonmotor symptoms scale (NMSS) and unified Parkinson's disease rating scale (UPDRS) that have a specific nonmotor domain will assist in defining research and therapy to enhance the early identification and management of NMS in the affected population.

AIM OF THE STUDY

(1) To evaluate the prevalence of NMS in different stages of idiopathic Parkinson's disease. (2) To correlate the prevalence of NMS with the duration and severity of the disease.

MATERIALS AND METHODS

The study involved 80 individuals who visited the Movement Disorder Clinic at Stanley Medical College and Hospital in Chennai and were diagnosed with idiopathic Parkinson's disease, which was in agreement with the United Kingdom Parkinson's Disease (UK PD) Brain Bank criteria.

RESULTS

Out of the 80 study participants, 63.7% ( = 51) were male and 36.3% ( = 29) were female. In our study, the mean age of patients was 63.1 ± 7.01 years. The study population was predominantly aged 50-60 years ( = 36), followed by 61-70 years ( = 30), which made up more than 80% of the population. Age group of >71 years constituted only 17.5% ( = 14). Majority of the patients, that is, 42.5% ( = 34) were in stage 3 of Hoehn and Yahr (H&Y) staging. The mean and mode of H&Y stage were 2.7 ± 0.9 and 3, respectively. The mean duration of disease was 4.7 ± 2.7 years. The mean UPDRS score was 66 ± 24.5. The mean NMSS score was 32 ± 10.18.

CONCLUSION

NMSs are found to be highly prevalent among Indian patients with PD according to this study. The nonmotor symptom questionnaire aids in early detection and recognition of nonmotor symptoms in PD patients.

摘要

概述

帕金森病（PD）是一种神经退行性疾病，在50岁以上人群中较为常见，约影响1%的人口。非运动症状（NMS）在帕金森病中很常见，但常被运动症状所掩盖。研究表明，帕金森病中的非运动症状对生活质量有显著影响。引入具有特定非运动领域的工具，如非运动症状量表（NMSS）和统一帕金森病评定量表（UPDRS），将有助于确定研究和治疗方法，以加强对受影响人群中非运动症状的早期识别和管理。

研究目的

（1）评估特发性帕金森病不同阶段非运动症状的患病率。（2）将非运动症状的患病率与疾病的持续时间和严重程度相关联。

材料与方法

该研究纳入了80名前往金奈斯坦利医学院医院运动障碍门诊就诊并被诊断为特发性帕金森病的患者，诊断符合英国帕金森病脑库标准。

结果

80名研究参与者中，63.7%（n = 51）为男性，36.3%（n = 29）为女性。在我们的研究中，患者的平均年龄为63.1 ± 7.01岁。研究人群主要为50 - 60岁（n = 36），其次是61 - 70岁（n = 30），这两组占总人数的80%以上。71岁以上年龄组仅占17.5%（n = 14）。大多数患者，即42.5%（n = 34）处于Hoehn和Yahr（H&Y）分期的3期。H&Y分期的平均值和众数分别为2.7 ± 0.9和3。疾病的平均持续时间为4.7 ± 2.7年。UPDRS平均评分为66 ± 24.5。NMSS平均评分为32 ± 10.18。