Neurology Clinic, Etlik City Hospital, Ankara, Turkey.
Neurol Res. 2024 Nov;46(11):1054-1062. doi: 10.1080/01616412.2024.2381162. Epub 2024 Aug 28.
The objective was to determine the prevalence and clinical correlates of nonmotor symptoms in Parkinson's disease patients in movement disorders outpatient clinics.
We enrolled all consecutive PD patients who visited our movement disorders outpatient clinics between January and December 2023; and agreed to participate in the study. In addition to the evaluation of demographic and clinical features, clinical scales, including the MDS-UPDRS, NMSS, and FOOGQ, were performed.
Overall, we enrolled 163 PD subjects with a mean age of 63.9 ± 10.4 (F/M = 27/136). The disease duration was 3.5 (20) y [median (range)]. The median score of the NMSS was 41 points. The NMSs burden levels were severe in 25.2%, and very severe in 25.2% of the subjects. The subitems with the highest scores were sleep/fatigue, mood/cognition, urinary, and miscellaneous. The analyses within the patient group with newly diagnosed PD also revealed high NMSS scores. Comparisons of the NMSS between distinct PD stages revealed greater NMSS scores in the severe stage than in the mild stage ( = 0.001). Correlation analyses between the clinical scores and the NMSS scores revealed positive correlations between the NMSS scores and the scores on all the clinical scales including the MDS-UPDRS 1-4, and FOGQ.
We reported the first data regarding the NMS burden in PD patients from Turkey. We found a high prevalence and severity of various domains of NMSs, most of which were sleep/fatigue, mood/cognition, urinary, and miscellaneous. More than half of the patients had severe to very severe NMS burden. Although NMSs were more common severe-stage disease, they were also prevalent in the subgroup with newly diagnosed patients.
旨在确定运动障碍门诊中帕金森病患者非运动症状的患病率和临床相关性。
我们纳入了 2023 年 1 月至 12 月期间在我们运动障碍门诊就诊的所有连续帕金森病患者；并同意参与研究。除了评估人口统计学和临床特征外，还进行了临床量表评估，包括 MDS-UPDRS、NMSS 和 FOOGQ。
我们共纳入了 163 名帕金森病患者，平均年龄为 63.9±10.4（F/M=27/136）。疾病持续时间为 3.5（20）年[中位数（范围）]。NMSS 的中位数评分为 41 分。25.2%的患者 NMSs 负担程度严重，25.2%的患者非常严重。得分最高的子项是睡眠/疲劳、情绪/认知、尿便和杂项。在新诊断为 PD 的患者组内的分析也显示出 NMSS 评分较高。对不同 PD 阶段的 NMSS 进行比较发现，严重阶段的 NMSS 评分高于轻度阶段（ = 0.001）。临床评分与 NMSS 评分之间的相关性分析显示，NMSS 评分与所有临床量表的评分呈正相关，包括 MDS-UPDRS 1-4 和 FOGQ。
我们报告了来自土耳其的关于帕金森病患者 NMS 负担的第一项数据。我们发现各种 NMS 领域的高患病率和严重程度，其中大多数是睡眠/疲劳、情绪/认知、尿便和杂项。超过一半的患者有严重到非常严重的 NMS 负担。尽管 NMSs 在疾病更严重的阶段更为常见，但在新诊断的患者亚组中也很常见。
