Kim Jin Hee, Choi Yujin, Lee Seungmin, Oh Myung Sook
Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Department of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomol Ther (Seoul). 2025 Jan 1;33(1):54-74. doi: 10.4062/biomolther.2024.215. Epub 2024 Dec 16.
Neurodegenerative diseases (NDDs), characterized by the progressive deterioration of the structure and function of the nervous system, represent a significant global health challenge. Emerging research suggests that the gut microbiota plays a critical role in regulating neurodegeneration via modulation of the gut-brain axis. Probiotics, defined as live microorganisms that confer health benefits to the host, have garnered significant attention owing to their therapeutic potential in NDDs. This review examines the current research trends related to the microbiome-gut-brain axis across various NDDs, highlighting key findings and their implications. Additionally, the effects of specific probiotic strains, including , , and , on neurodegenerative processes were assessed, focusing on their potential therapeutic benefits. Overall, this review emphasizes the potential of probiotics as promising therapeutic agents for NDDs, underscoring the importance of further investigation into this emerging field.
神经退行性疾病（NDDs）以神经系统结构和功能的进行性恶化为特征，是全球重大的健康挑战。新出现的研究表明，肠道微生物群通过调节肠-脑轴在调节神经退行性变中起关键作用。益生菌被定义为对宿主有益健康的活微生物，因其在神经退行性疾病中的治疗潜力而备受关注。本综述探讨了各种神经退行性疾病中与微生物群-肠-脑轴相关的当前研究趋势，强调了关键发现及其意义。此外，还评估了包括[具体菌株1]、[具体菌株2]和[具体菌株3]在内的特定益生菌菌株对神经退行性过程的影响，重点关注它们潜在的治疗益处。总体而言，本综述强调了益生菌作为神经退行性疾病有前景的治疗药物的潜力，强调了进一步研究这一新兴领域的重要性。
