Denniston C
Environ Mutagen. 1985;7(1):53-72. doi: 10.1002/em.2860070103.
A screening program is defined to include a set of tests, a decision function, and a protocol. The major characteristics of a screening program are the error rates of the individual tests, the overall error rates of the program, the costs of the individual tests, and the overall program costs. It is shown how to calculate the program error rates for any given decision function. The concept of a screening protocol is developed and a method for enumerating all protocols of a given decision function is given. A given protocol has two calculable costs: the average cost of testing a mutagen and the average cost of calculating a nonmutagen. A method for calculating these costs for any protocol is given. All decision functions utilizing up to five tests are enumerated.
一个筛查程序被定义为包括一组测试、一个决策函数和一个方案。筛查程序的主要特征是各个测试的错误率、程序的总体错误率、各个测试的成本以及程序的总体成本。展示了如何针对任何给定的决策函数计算程序错误率。提出了筛查方案的概念，并给出了一种枚举给定决策函数的所有方案的方法。一个给定的方案有两个可计算的成本：检测一个诱变剂的平均成本和计算一个非诱变剂的平均成本。给出了一种针对任何方案计算这些成本的方法。列举了所有使用多达五项测试的决策函数。
