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大规模筛查项目中短期致突变性试验应用相关的问题。

Problems associated with the application of short-term tests for mutagenicity in mass-screening programs.

作者信息

de Serres F J

出版信息

Environ Mutagen. 1979;1(3):203-8. doi: 10.1002/em.2860010302.

DOI:10.1002/em.2860010302
PMID:399909
Abstract

The application of short-term tests for toxicological evaluation of environmental chemicals is certainly a reality in the near future as a result of the Toxic Substances Control Act, as well as other regulations under development [de Serres, 1977]. Many of the problems associated with this testing in the area of genetic toxicology are under study at the National Institute of Environmental Health Sciences in our National Toxicology Program and at the Environmental Protection Agency in their Gene-Tox Program. The other problems that I have discussed in connection with standardization of protocols, protocol review and modification, and training of personnel are not being pursued aggressively. Perhaps with their definition and acceptance as meaningful problems, mechanisms will be established for their resolution. It is in these latter areas that I hope that this society can provide the forceful leadership that will result in their resolution in the near future.

摘要

由于《有毒物质控制法》以及其他正在制定的法规,短期内对环境化学品进行毒理学评估测试在不久的将来必将成为现实[德塞雷斯,1977年]。国家环境卫生科学研究所的国家毒理学计划以及环境保护局的基因毒性计划正在研究遗传毒理学领域中与该测试相关的许多问题。我所讨论的与方案标准化、方案审查与修改以及人员培训相关的其他问题并未得到积极推进。或许随着这些问题被界定并被认可为有意义的问题,将会建立起解决它们的机制。正是在这些后一类领域,我希望这个协会能够发挥强有力的领导作用,从而在不久的将来促成这些问题的解决。

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引用本文的文献

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Induction of gene mutation in and cell transformation of mammalian cells by modified purines: 2-aminopurine and 6-N-hydroxylaminopurine.修饰嘌呤对哺乳动物细胞的基因突变诱导及细胞转化作用:2-氨基嘌呤和6-N-羟氨基嘌呤。
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5685-9. doi: 10.1073/pnas.78.9.5685.
3
Germinal cell mutagenesis in specially designed maize genotypes.在特殊设计的玉米基因型中的生殖细胞诱变
Environ Health Perspect. 1981 Jan;37:61-73. doi: 10.1289/ehp.813761.