Lee Y Z, Leighton F A, Peakall D B, Norstrom R J, O'Brien P J, Payne J F, Rahimtula A D
Environ Res. 1985 Feb;36(1):248-55. doi: 10.1016/0013-9351(85)90022-2.
Oral administration of Prudhoe Bay crude or Hibernia crude to nestling herring gulls increased the hepatic cytochrome P-450 content 4-fold. Concomitantly, there was an increase in various mixed-function oxidase and phase II enzyme activities. 7-Ethoxyresorufin O-deethylase was elevated 19-fold, benzo(a)pyrene 3-hydroxylase 6-fold, aniline hydroxylase 3-fold, and aminopyrine N-demethylase and uridine diphosphate glucuronyl transferase 2-fold. There was no change in reduced glutathione S-transferase activity. Renal mixed-function oxidase activities were also elevated. Herring gull livers contained very low levels of DT-diaphorase activity which was inducible 3- to 5-fold by oil administration.
给雏环嘴鸥口服普拉德霍湾原油或希伯尼亚原油，可使肝脏细胞色素P - 450含量增加4倍。与此同时，各种混合功能氧化酶和II相酶的活性也有所增加。7 - 乙氧基异吩恶唑酮O - 脱乙基酶升高了19倍，苯并(a)芘3 - 羟化酶升高了6倍，苯胺羟化酶升高了3倍，氨基比林N - 脱甲基酶和尿苷二磷酸葡萄糖醛酸转移酶升高了2倍。还原型谷胱甘肽S - 转移酶的活性没有变化。肾脏混合功能氧化酶的活性也有所升高。环嘴鸥肝脏中DT - 黄递酶的活性非常低，通过给予原油可诱导其活性提高3至5倍。
