[植物名称]地上部分的二萜类和三萜类化合物及其生物活性
Diterpenoids and Triterpenoids from the Aerial Parts of and Their Biological Activities.
作者信息
Ren Wen-Jing, Jiang Rong, Ng Kei-Fong, Bao Meng-Yu, Liu Xiao-Mei, Zhang Wei, Jiang Zhi-Hong, Liu Yu-Hong, Zhu Guo-Yuan
机构信息
State Key Laboratory of Quality Research in Chinese Medicine, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau 999078, People's Republic of China.
School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan 250355, People's Republic of China.
出版信息
ACS Omega. 2024 Nov 22;9(49):48791-48801. doi: 10.1021/acsomega.4c08821. eCollection 2024 Dec 10.
Five undescribed diterpenoids, serranins A-E (-), and four novel triterpenoids, serratic acids A-D (-), along with 32 known terpenoids (-) were isolated from the aerial parts of . The planar structures of - and their relative configurations were established on the basis of extensive spectroscopic analysis. Structurally, compounds - are the first examples of 18,19--ursane -coumaric or ferulic esters, while compounds - further enriched the plant's diterpene profile. Bioactivity evaluation revealed that four diterpenoids (, , , and ) exhibited potent cytotoxic activity against four cancer cell lines (B16-F10, A375, A549, and MDA-MB-231) with IC values below 10 μM. Remarkably, and exhibited a comparable antimelanogenesis effect to that of positive control (kojic acid) in B16-F10 cells.
从[植物名称]地上部分分离得到了5个未描述的二萜类化合物，serratanins A - E（-），4个新的三萜类化合物，serratic acids A - D（-），以及32个已知的萜类化合物（-）。通过广泛的光谱分析确定了[化合物名称]的平面结构及其相对构型。在结构上，化合物[具体化合物]是18,19 - 乌苏烷 - 香豆酸或阿魏酸酯的首个实例，而化合物[具体化合物]进一步丰富了该植物的二萜类成分。生物活性评价表明，4个二萜类化合物（[具体化合物]）对4种癌细胞系（B16 - F10、A375、A549和MDA - MB - 231）表现出强效细胞毒性活性（IC值低于10 μM）。值得注意的是，[具体化合物]在B16 - F10细胞中表现出与阳性对照（曲酸）相当的抗黑色素生成作用。
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