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一例诊断不明的涎腺透明细胞肿瘤：罕见病例报告

A Salivary Clear Cell Tumor With an Unclear Diagnosis: A Report of a Rare Case.

作者信息

Strokov Svyat, Helène Raybaud, Cardot-Leccia Nathalie, Dadone-Montaudié Bérangère, Voha Christine

机构信息

Oral Pathology, Faculté de Chirurgie Dentaire, Université Côte d'Azur, Nice, FRA.

Oral Pathology, Institut de Médecine Bucco-Dentaire, Centre Hospitalier Universitaire (CHU) de Nice, Nice, FRA.

出版信息

Cureus. 2024 Nov 14;16(11):e73656. doi: 10.7759/cureus.73656. eCollection 2024 Nov.

DOI:10.7759/cureus.73656
PMID:39677248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11646157/
Abstract

The histopathological diagnosis of salivary tumors is considered complex, due to their histological, phenotypic, and genotypic diversity. There are numerous tumors with morphological and/or immunohistochemical aspects that are superimposable but require very different treatment. In this context, salivary lesions containing clear cells are numerous and form part of the diagnostic challenges. We present the case of a 63-year-old woman with a tumor of the accessory salivary glands of the palate, with a predominant clear cell contingent. The aim of this paper is to report a case of a clear cell salivary tumor and to detail the difficulties of differential diagnosis, highlighting new data in the literature and the role of molecular biology.

摘要

由于唾液腺肿瘤在组织学、表型和基因型上具有多样性，其组织病理学诊断被认为很复杂。有许多肿瘤在形态学和/或免疫组化方面有重叠，但需要非常不同的治疗方法。在这种情况下，含有透明细胞的唾液腺病变很多，构成了诊断挑战的一部分。我们报告一例63岁女性腭部副唾液腺肿瘤的病例，其中透明细胞占主要成分。本文的目的是报告一例透明细胞唾液腺肿瘤病例，并详细说明鉴别诊断的困难，突出文献中的新数据以及分子生物学的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/637a2bf88785/cureus-0016-00000073656-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/bb15b501b3b2/cureus-0016-00000073656-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/46cfba51b8cf/cureus-0016-00000073656-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/366ce77aa258/cureus-0016-00000073656-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/c3d8c606f0e3/cureus-0016-00000073656-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/637a2bf88785/cureus-0016-00000073656-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/bb15b501b3b2/cureus-0016-00000073656-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/46cfba51b8cf/cureus-0016-00000073656-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/366ce77aa258/cureus-0016-00000073656-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/c3d8c606f0e3/cureus-0016-00000073656-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3cf/11646157/637a2bf88785/cureus-0016-00000073656-i05.jpg

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本文引用的文献

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Mucoepidermoid carcinoma may be devoid of squamoid cells by immunohistochemistry: expanding the histologic and immunohistochemical spectrum of MAML2- rearranged salivary gland tumours.黏液表皮样癌通过免疫组织化学检查可能缺乏鳞状细胞：扩展MAML2重排唾液腺肿瘤的组织学和免疫组织化学谱。
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The evolving role of molecular pathology in the diagnosis of salivary gland tumours with potential pitfalls.
分子病理学在唾液腺肿瘤诊断中的作用演变及其潜在陷阱。
Eur Arch Otorhinolaryngol. 2022 Aug;279(8):3769-3783. doi: 10.1007/s00405-022-07326-6. Epub 2022 Mar 10.
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Clear Cell Neoplasms of Salivary Glands: A Diagnostic Challenge.唾液腺透明细胞肿瘤：诊断挑战。
Adv Anat Pathol. 2022 Jul 1;29(4):217-226. doi: 10.1097/PAP.0000000000000339. Epub 2022 Mar 7.
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Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland-A 26-Year, Clinicopathologic, Retrospective Analysis.波兰南部原发性上皮性涎腺肿瘤的流行病学——一项为期26年的临床病理回顾性分析
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Differential Diagnosis between Oral Metastasis of Renal Cell Carcinoma and Salivary Gland Cancer.肾细胞癌口腔转移与唾液腺癌的鉴别诊断
Diagnostics (Basel). 2021 Mar 12;11(3):506. doi: 10.3390/diagnostics11030506.
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Prognostic impact of CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma: A multiinstitutional retrospective study.CRTC1/3-MAML2 融合对唾液腺黏液表皮样癌预后的影响：一项多机构回顾性研究。
Cancer Sci. 2020 Nov;111(11):4195-4204. doi: 10.1111/cas.14632. Epub 2020 Sep 14.
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