High-Dose Epidermal Radionuclide Therapy with Re (Rhenium) Resin in a Patient with Multiple Actinic Keratoses.

High-dose epidermal radionuclide therapy using a nonsealed Re (Rhenium) resin is an alternative treatment option for nonmelanoma skin cancer. In this case study, we present the possible use of this therapy in a patient with multiple actinic keratosis (AK), which is a precancer of the skin.  A 55-year-old male was presented in our department with multiple AK, located on the cheek, temporal, and frontal area, with 1, 1, 2.1, and 2.5 cm surface. Applied activity was 80, 80, 167, and 168 MBq Re with a target absorbed dose for each lesion 35 Gy at 1 mm. The treatment was well tolerated.  At 17 months' follow-up, all treated area showed complete remission. There were no side effects, except mild focal hypopigmentation.  This case demonstrates the high potential of epidermal radionuclide therapy with a nonsealed Re as a noninvasive, effective, and well-tolerated therapy option for patients with multiple AK, when surgery is difficult to perform or not recommended of other reasons.