甲基纤维素处理的受辐照小鼠的内源性脾集落与巨核细胞生成
Endogenous splenic colonies and megakaryopoiesis in methylcellulose treated irradiated mice.
作者信息
Bernabei P A, Di Lollo S, Saccardi R, Arganini L, Pecoraro A, Rossi Ferrini P
出版信息
Experientia. 1985 Jan 15;41(1):97-9. doi: 10.1007/BF02005895.
PMID:3967747
Abstract
Endogenous splenic colonies are increased in methylcellulose-treated irradiated mice, 10 days after sublethal irradiation (450 R). The spleen shows an enhancement of megakaryopoiesis, especially localized around foam-cell foci. This suggests that the macrophage system, activated through phagocytic activity against methylcellulose, affects megakaryopoiesis by a microenvironmental mechanism.
摘要
在接受亚致死剂量照射（450拉德）10天后，甲基纤维素处理的受照射小鼠体内的内源性脾集落数量增加。脾脏显示巨核细胞生成增强，尤其集中在泡沫细胞灶周围。这表明，通过对甲基纤维素的吞噬活性激活的巨噬细胞系统，通过微环境机制影响巨核细胞生成。
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