Zhou Luhan T, Gokyer Dilan, Madkins Krystal, Beestrum Molly, Horton Daniel E, Duncan Francesca E, Babayev Elnur
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Galter Health Sciences Library & Learning Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
bioRxiv. 2024 Dec 5:2024.12.04.626831. doi: 10.1101/2024.12.04.626831.
Climate change is driving significant environmental changes with profound implications for human health, including fertility. While the detrimental effects of heat on spermatogenesis are well-documented, the impact of elevated temperatures on ovaries and female fertility remains less explored. This review systematically examines the literature on heat stress (HS) effects on mammalian ovaries, follicles, and oocytes. Evidence from mammalian models indicates that HS significantly impairs ovarian function, disrupting hormone profiles, reducing ovarian size and weight, altering histology, decreasing granulosa cell viability, and compromising oocyte quality. Efforts to develop strategies and substances to mitigate these adverse effects are ongoing, but further research into the underlying mechanisms is urgently needed.
气候变化正在推动重大的环境变化，对包括生育能力在内的人类健康产生深远影响。虽然高温对精子发生的有害影响已有充分记录，但高温对卵巢和女性生育能力的影响仍有待深入研究。本综述系统地研究了有关热应激（HS）对哺乳动物卵巢、卵泡和卵母细胞影响的文献。来自哺乳动物模型的证据表明，热应激会显著损害卵巢功能，扰乱激素水平，减小卵巢大小和重量，改变组织学结构，降低颗粒细胞活力，并损害卵母细胞质量。目前正在努力制定减轻这些不利影响的策略和物质，但迫切需要对潜在机制进行进一步研究。
