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体重指数对乳腺癌预后的影响：聚焦雌激素受体/孕激素受体状态及亚型特异性复发风险

Effect of body mass index on breast cancer prognosis: a focus on ER/PR status and subtype-specific recurrence risk.

作者信息

Shen Qinyan, Zhao Liangying, Lu Minjun

机构信息

Department of Surgical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical University Dongyang 322100, Zhejiang, China.

出版信息

Am J Transl Res. 2024 Nov 15;16(11):6467-6476. doi: 10.62347/WJIQ1560. eCollection 2024.

DOI:10.62347/WJIQ1560
PMID:39678546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11645606/
Abstract

OBJECTIVE

To explore prognostic differences in breast cancer (BC) recurrence risk across estrogen receptor (ER) and progesterone receptor (PR) defined subtypes, stratified by body mass index (BMI) categories, aiming to identify potential mechanisms.

METHODS

A cohort of 358 breast cancer patients provided data on height, weight, menopausal status, and receptor profiles for analysis.

RESULTS

Our findings highlighted that BMI's impact on BC prognosis was significantly influenced by ER/PR tumor status. In premenopausal women, BMI notably affected recurrence rates, especially in patients with ER-positive and PR-positive subtypes.

CONCLUSIONS

Adjusting treatment strategies based on BMI across different menopausal statuses and tumor subtypes could improve outcome for patients with ER-positive/PR-positive tumors.

摘要

目的

探讨根据雌激素受体（ER）和孕激素受体（PR）定义的亚型，按体重指数（BMI）类别分层的乳腺癌（BC）复发风险的预后差异，旨在确定潜在机制。

方法

一组358例乳腺癌患者提供了身高、体重、绝经状态和受体特征数据用于分析。

结果

我们的研究结果突出表明，BMI对BC预后的影响受ER/PR肿瘤状态的显著影响。在绝经前女性中，BMI显著影响复发率，尤其是在ER阳性和PR阳性亚型的患者中。

结论

根据不同绝经状态和肿瘤亚型的BMI调整治疗策略，可改善ER阳性/PR阳性肿瘤患者的预后。

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本文引用的文献

1
The impact of BMI on breast cancer - an updated systematic review and meta-analysis.BMI 对乳腺癌的影响 - 一项更新的系统评价和荟萃分析。
Medicine (Baltimore). 2024 Feb 2;103(5):e36831. doi: 10.1097/MD.0000000000036831.
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Association of physical weight statuses defined by body mass index (BMI) with molecular subtypes of premenopausal breast cancer: a systematic review and meta-analysis.基于体重指数（BMI）定义的体质量状况与绝经前乳腺癌分子亚型的关联：系统评价和荟萃分析。
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Extensive review on breast cancer its etiology, progression, prognostic markers, and treatment.乳腺癌的病因、进展、预后标志物及治疗的全面综述。
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Cancers (Basel). 2023 Apr 28;15(9):2526. doi: 10.3390/cancers15092526.
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Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort.不同 BMI 乳腺癌女性全身炎症和胰岛素抵抗的综合预后影响：一项前瞻性多中心队列研究。
Sci Rep. 2023 Mar 15;13(1):4303. doi: 10.1038/s41598-023-31450-w.
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Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers.肥胖驱动的乳腺癌相关效应的预防与治疗进展
Front Oncol. 2022 Jun 22;12:820968. doi: 10.3389/fonc.2022.820968. eCollection 2022.
7
The obesity-breast cancer link: a multidisciplinary perspective.肥胖与乳腺癌的关联：多学科视角。
Cancer Metastasis Rev. 2022 Sep;41(3):607-625. doi: 10.1007/s10555-022-10043-5. Epub 2022 Jun 25.
8
Associations of adiposity and weight change with recurrence and survival in breast cancer patients: a systematic review and meta-analysis.肥胖和体重变化与乳腺癌患者复发和生存的关联：系统评价和荟萃分析。
Breast Cancer. 2022 Jul;29(4):575-588. doi: 10.1007/s12282-022-01355-z. Epub 2022 May 17.
9
Global Increase in Breast Cancer Incidence: Risk Factors and Preventive Measures.全球乳腺癌发病率上升：风险因素和预防措施。
Biomed Res Int. 2022 Apr 18;2022:9605439. doi: 10.1155/2022/9605439. eCollection 2022.
10
Estrogen Receptor Function: Impact on the Human Endometrium.雌激素受体功能：对人子宫内膜的影响。
Front Endocrinol (Lausanne). 2022 Feb 28;13:827724. doi: 10.3389/fendo.2022.827724. eCollection 2022.