体重指数对乳腺癌预后的影响：聚焦雌激素受体/孕激素受体状态及亚型特异性复发风险
Effect of body mass index on breast cancer prognosis: a focus on ER/PR status and subtype-specific recurrence risk.
作者信息
Shen Qinyan, Zhao Liangying, Lu Minjun
机构信息
Department of Surgical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical University Dongyang 322100, Zhejiang, China.
出版信息
Am J Transl Res. 2024 Nov 15;16(11):6467-6476. doi: 10.62347/WJIQ1560. eCollection 2024.
Abstract
OBJECTIVE
To explore prognostic differences in breast cancer (BC) recurrence risk across estrogen receptor (ER) and progesterone receptor (PR) defined subtypes, stratified by body mass index (BMI) categories, aiming to identify potential mechanisms.
METHODS
A cohort of 358 breast cancer patients provided data on height, weight, menopausal status, and receptor profiles for analysis.
RESULTS
Our findings highlighted that BMI's impact on BC prognosis was significantly influenced by ER/PR tumor status. In premenopausal women, BMI notably affected recurrence rates, especially in patients with ER-positive and PR-positive subtypes.
CONCLUSIONS
Adjusting treatment strategies based on BMI across different menopausal statuses and tumor subtypes could improve outcome for patients with ER-positive/PR-positive tumors.
摘要
目的
探讨根据雌激素受体（ER）和孕激素受体（PR）定义的亚型，按体重指数（BMI）类别分层的乳腺癌（BC）复发风险的预后差异，旨在确定潜在机制。
方法
一组358例乳腺癌患者提供了身高、体重、绝经状态和受体特征数据用于分析。
结果
我们的研究结果突出表明，BMI对BC预后的影响受ER/PR肿瘤状态的显著影响。在绝经前女性中，BMI显著影响复发率，尤其是在ER阳性和PR阳性亚型的患者中。
结论
根据不同绝经状态和肿瘤亚型的BMI调整治疗策略，可改善ER阳性/PR阳性肿瘤患者的预后。
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本文引用的文献
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