Public Health and Medical Research, Charisma University, Grace Bay, Turks and Caicos Islands, Train to Teach in Medicine, Department of Postgraduate Medical Education, Harvard Medical School, MCPHS University, Boston, MA.
Clinical Research, TRG GEN+, Beirut, Lebanon.
Medicine (Baltimore). 2024 Feb 2;103(5):e36831. doi: 10.1097/MD.0000000000036831.
Breast cancer is the most frequent form of cancer in women all over the world. It is the main cause of cancer death and the most often diagnosed cancer in women in 140 of the world's 184 countries. The link between breast cancer risk and body mass index (BMI) has gotten increasing attention in recent years, although the results are still debatable. Therefore, the current systematic review and meta-analysis evaluate the impact of BMI on breast cancer.
The current study was carried out as a systematic review and meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We systematically searched Cochrane, Google Scholar, PubMed, EMBASE and Scopus databases to identify eligible articles impact of BMI on breast cancer with the appropriate Medical Subject Headings (MeSH). The Newcastle-Ottawa checklist was used for the risk of assessment for the included studies. Meta-analysis was performed using Review Manager 5.3 software.
Forty-six studies were included in the current review, which met the selection criteria of the current review. Among included 46 studies in this review, 50% (n = 23) of the studies found the HER2 type of breast cancer followed by triple-negative and HR-positive. The obesity was significantly higher in the case group compared with the control group (P < .001). Heterogeneity between the 14 studies is medium (I2 = 72%). In this review, there was no significant relation between overweight and breast cancer in women (P > .05). Heterogenecity between the 14 studies is medium (I2 = 89%). However, after removing the publication bias a significant relation between overweightness and breast cancer in women (P = .0005) was observed.
Obese breast cancer patients are a specific type of patient. They are more likely to develop cancer. Their need to surgery and radiation may cause greater difficulties. Obesity and overweight in women greatly increase the risk of breast cancer, according to the findings of the current meta-analysis. To confirm these findings and understand the pathogenic pathways, more research is required.
乳腺癌是全世界女性最常见的癌症类型。它是癌症死亡的主要原因，也是全球 184 个国家/地区中 140 个国家/地区女性中最常被诊断出的癌症。近年来，乳腺癌风险与体重指数（BMI）之间的联系受到了越来越多的关注，尽管结果仍存在争议。因此，目前的系统评价和荟萃分析评估了 BMI 对乳腺癌的影响。
本研究按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行了系统评价和荟萃分析。我们系统地检索了 Cochrane、Google Scholar、PubMed、EMBASE 和 Scopus 数据库，以确定符合条件的文章，这些文章使用适当的医学主题词（MeSH）评估了 BMI 对乳腺癌的影响。使用纽卡斯尔-渥太华量表对纳入研究进行风险评估。使用 Review Manager 5.3 软件进行荟萃分析。
本综述共纳入 46 项符合选择标准的研究。在本综述中纳入的 46 项研究中，有 50%（n=23）的研究发现 HER2 型乳腺癌紧随三阴性和 HR 阳性乳腺癌之后。病例组的肥胖率明显高于对照组（P<0.001）。14 项研究之间的异质性为中等（I2=72%）。在本综述中，超重与女性乳腺癌之间没有显著关系（P>0.05）。14 项研究之间的异质性为中等（I2=89%）。然而，在去除发表偏倚后，观察到超重与女性乳腺癌之间存在显著关系（P=0.0005）。
肥胖的乳腺癌患者是一种特殊类型的患者。他们更有可能患上癌症。他们对手术和放疗的需求可能会带来更大的困难。根据本次荟萃分析的结果，女性肥胖和超重会大大增加患乳腺癌的风险。为了证实这些发现并了解发病机制，需要开展更多的研究。
