Zhu Fengya, Yin Shao, Wang Yuan, Zhong Yue, Ji Qiang, Wu Jie
Traditional Chinese Medicine Department, Zigong First People's Hospital, Zigong, People's Republic of China.
Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Int J Gen Med. 2024 Dec 10;17:5941-5958. doi: 10.2147/IJGM.S499406. eCollection 2024.
In recent years, probiotics, as a class of biologically active microorganisms, have increasingly attracted attention for their potential in treating neurodegenerative diseases (NDDs). To comprehensively assess the effects of probiotics on clinical symptoms and systemic inflammation regulation in various NDDs, this systematic review conducted a detailed search of the Cochrane Library, Embase, PubMed, and Web of Science databases, ultimately including 22 eligible randomized controlled trials (RCTs), with 4 RCTs for Alzheimer's Disease (AD), 10 RCTs for Parkinson's Disease (PD), 2 RCTs for Multiple Sclerosis (MS), and 2 RCTs for Mild Cognitive Impairment (MCI), and intervention durations ranging from 4 to 16 weeks. The comprehensive analysis indicates that probiotics help improve clinical symptoms related to NDDs, including gastrointestinal function, cognitive function, quality of life, and mental health. Additionally, probiotics generally have a positive effect on reducing systemic inflammation and enhancing antioxidant capacity in patients. In conclusion, existing evidence supports the promising potential of probiotics in treating NDDs. However, further large-scale, high-quality studies are needed to explore specific differences in efficacy among various probiotic strains, dosages, and modes of administration. Moreover, considering that lifestyle and dietary habits may modulate the effects of probiotics, these external factors should also be included in research considerations to gain a more comprehensive understanding of the mechanisms and application strategies of probiotics in NDDs treatment.
近年来，益生菌作为一类生物活性微生物，因其在治疗神经退行性疾病（NDDs）方面的潜力而越来越受到关注。为了全面评估益生菌对各种NDDs临床症状和全身炎症调节的影响，本系统评价对Cochrane图书馆、Embase、PubMed和Web of Science数据库进行了详细检索，最终纳入22项符合条件的随机对照试验（RCT），其中4项针对阿尔茨海默病（AD），10项针对帕金森病（PD），2项针对多发性硬化症（MS），2项针对轻度认知障碍（MCI），干预持续时间为4至16周。综合分析表明，益生菌有助于改善与NDDs相关的临床症状，包括胃肠功能、认知功能、生活质量和心理健康。此外，益生菌通常对降低患者全身炎症和增强抗氧化能力有积极作用。总之，现有证据支持益生菌在治疗NDDs方面具有广阔的潜力。然而，需要进一步开展大规模、高质量的研究，以探索不同益生菌菌株、剂量和给药方式在疗效上的具体差异。此外，考虑到生活方式和饮食习惯可能会调节益生菌的作用，这些外部因素也应纳入研究考虑范围，以便更全面地了解益生菌在NDDs治疗中的作用机制和应用策略。
