Sil Abheek, Chakraborty Disha
From the Department of Dermatology, PKG Medical College and Hospital, Sacramento, California, USA.
Department of Dermatology, Rheumatology and Immunology, University of California, Davis VA Medical Center, Sacramento, California, USA.
Indian J Dermatol. 2024 Nov-Dec;69(6):486. doi: 10.4103/ijd.ijd_568_23. Epub 2024 Oct 29.
Engagement of microribonucleic acids (miRNA) in the regulation of cutaneous cellular health and diseases is a rapidly advancing niche in dermatology basic research. miRNAs have been identified to play a key role in the pathogenesis of various cutaneous inflammatory, autoimmune and neoplastic conditions, among others. In addition, their purported role as therapeutic targets and biomarkers in diseased conditions harbours exciting news for the approaching years in clinical research. The current review outlines the possible translational role of miRNA in skin health and diseases (encompassing pathogenesis, diagnosis, biomarkers and therapy) from bench to bedside.
微小核糖核酸(miRNA)参与皮肤细胞健康和疾病的调节,这是皮肤病学基础研究中一个快速发展的领域。已确定miRNA在各种皮肤炎症、自身免疫和肿瘤性疾病等的发病机制中起关键作用。此外,它们在疾病状态下作为治疗靶点和生物标志物的潜在作用,为临床研究的未来几年带来了令人兴奋的消息。本综述概述了miRNA在皮肤健康和疾病(包括发病机制、诊断、生物标志物和治疗)中从实验室到临床的可能转化作用。