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古吉拉特邦索拉什特拉地区抗菌药物耐药性的流行情况及其对可持续医疗保健的影响

Prevalence of Antimicrobial Resistance in Saurashtra, Gujarat and Implications Toward Sustainable Healthcare.

作者信息

Banerjee Debashis, Das Mousumi, Chatterjee Avradip, Tank Sheetal, Aghera Nilesh

机构信息

Department of Biotechnology, Faculty of Science, Atmiya University, Rajkot, Gujarat 360005 India.

Department of Microbiology, Faculty of Science, Atmiya University, Rajkot, Gujarat 360005 India.

出版信息

Indian J Microbiol. 2024 Dec;64(4):1672-1679. doi: 10.1007/s12088-024-01209-6. Epub 2024 Feb 17.

Abstract

Growing antimicrobial resistance (AMR) is one of the major worldwide healthcare problems at present. Antimicrobial resistance (AMR) is part of the natural process of evolution among microorganisms, but which is expedited manifold by the unregulated and over-the-counter use of antibiotics. This induces new and more severe resistance mechanisms in the microbes, which is quite difficult to treat with the routinely prescribed antibiotics, ultimately leading to prolonged infections, disease and even death of the host. WHO had, back in 2014, issued a strict warning in its report about the rising incidence and future threat of AMR globally. So, the present epidemiological survey was carried out to evaluate the growing incidence of antimicrobial resistance in Rajkot, a city located in the western part of India. The data was collected from various clinical settings e.g., hospitals, clinics and diagnostic centers, situated across the city, which was later statistically evaluated for clinical significance. The results clearly indicated towards the rising prevalence of resistance in some of the important clinical pathogens for example, , etc., against some of commonly used antibiotics e.g. ampicillin, piperacillin, ciprofloxacin, levofloxacin and aztreonam. This study clearly highlights the danger and challenge of treating antibiotic resistant infections in future, also drawing attention to a similar crisis probably existing in various parts of the world. It is very crucial to control this situation in relevance to SDG goals also, as minimizing the prevalence and effect of diseases is an important target to achieve in Goal-3, that aims to promote healthy lives and well-being for all.

摘要

日益增长的抗菌药物耐药性(AMR)是当前全球主要的医疗保健问题之一。抗菌药物耐药性是微生物自然进化过程的一部分,但抗生素的无节制和非处方使用使其成倍加速。这在微生物中诱导出了新的、更严重的耐药机制,常规处方的抗生素很难治疗,最终导致感染延长、疾病甚至宿主死亡。早在2014年,世界卫生组织就在其报告中就全球抗菌药物耐药性发病率上升及未来威胁发出了严厉警告。因此,本次流行病学调查旨在评估印度西部城市拉杰果德抗菌药物耐药性的增长情况。数据收集自全市各地的各种临床机构,如医院、诊所和诊断中心,随后对其进行统计学评估以确定临床意义。结果清楚地表明,一些重要临床病原体(如……等)对一些常用抗生素(如氨苄西林、哌拉西林、环丙沙星、左氧氟沙星和氨曲南)的耐药率在上升。这项研究清楚地凸显了未来治疗抗生素耐药性感染的危险和挑战,也引起了人们对世界各地可能存在的类似危机的关注。与可持续发展目标相关联来控制这种情况也非常关键,因为将疾病的流行率和影响降至最低是目标3的一个重要目标,该目标旨在促进所有人的健康生活和福祉。

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