Lim P L, Rowley D
Int Arch Allergy Appl Immunol. 1985;76(1):25-9. doi: 10.1159/000233656.
The preparation of flagellin (FLA) from Salmonella adelaide and Boivin antigen (BA) from Vibrio cholerae is described. These two antigens differed chemically from each other and showed marked differences in their degradability by mouse intestinal juice in vitro and in their fate in the intact mouse when given intravenously. Unlike BA, FLA was rapidly degraded in intestinal juice and readily sequestered and degraded by the liver. The suitability of these antigens in oral absorption studies is discussed.
本文描述了从阿德莱德沙门氏菌制备鞭毛蛋白（FLA）以及从霍乱弧菌制备博伊文抗原（BA）的方法。这两种抗原在化学性质上彼此不同，在体外经小鼠肠液降解时以及静脉注射后在完整小鼠体内的命运方面表现出显著差异。与BA不同，FLA在肠液中迅速降解，并容易被肝脏摄取和降解。本文还讨论了这些抗原在口服吸收研究中的适用性。
