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口服吸收免疫原的加工处理

Processing of orally absorbed immunogen.

作者信息

Lim P L, Rowley D

出版信息

Int Arch Allergy Appl Immunol. 1982;68(2):182-4. doi: 10.1159/000233092.

DOI:10.1159/000233092
PMID:7076329
Abstract

The absorption of immunogen from the adult mouse intestine was demonstrated. This was shown indirectly by the ability of oral doses of a bacterial antigen to prime an animal for an anamnestic, systemic response, and directly by the ability of absorbed material from the plasma in vivo or everted gut sacs in vitro to prime normal mice when injected intravenously. In all cases, the resultant, systemic response in the recipient animals was qualitatively different (presumably due to IgA production) from that obtained in mice primed intravenously with the native antigen.

摘要

已证实免疫原可从小鼠成年肠道吸收。这一点通过口服细菌抗原能使动物引发回忆性全身反应间接得以证明,并且通过给正常小鼠静脉注射体内血浆或体外外翻肠囊吸收的物质能引发反应直接得以证明。在所有情况下,受体动物产生的全身反应在性质上与用天然抗原静脉免疫的小鼠所产生的反应不同(可能是由于IgA产生)。

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