Lu Xin-Yan, Jin Hongxu
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Emergency Medicine Department of General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Front Pharmacol. 2024 Nov 29;15:1486783. doi: 10.3389/fphar.2024.1486783. eCollection 2024.
Resistance to chemotherapeutic agents poses a significant challenge in cancer treatment, particularly with doxorubicin, a widely used drug for various cancers, including breast cancer, leukaemia, osteosarcoma, and gastrointestinal cancers. This review aims to elucidate the critical role of microRNAs (miRNAs) in the development of doxorubicin resistance, focusing on their interactions with ATP-binding cassette (ABC) transporters. Despite extensive research, the molecular mechanisms governing doxorubicin resistance still need to be completed, particularly regarding the regulatory influence of miRNAs on ABC transporter expression. By analyzing current literature, this review identifies a notable gap: the lack of comprehensive insight into how specific miRNAs modulate the expression and activity of ABC transporters in cancer cells, contributing to doxorubicin resistance. We systematically examine recent findings on the interplay between miRNAs and ABC transporters, providing a detailed assessment of potential therapeutic strategies that leverage miRNA modulation to overcome drug resistance. Ultimately, this review underscores the significance of integrating miRNA research into existing therapeutic frameworks to enhance the efficacy of doxorubicin in cancer treatment.
对化疗药物产生耐药性是癌症治疗中的一项重大挑战，尤其是对于阿霉素而言，它是一种广泛用于治疗包括乳腺癌、白血病、骨肉瘤和胃肠道癌在内的各种癌症的药物。本综述旨在阐明微小RNA（miRNA）在阿霉素耐药性发展中的关键作用，重点关注它们与ATP结合盒（ABC）转运蛋白的相互作用。尽管进行了广泛的研究，但控制阿霉素耐药性的分子机制仍有待完善，特别是关于miRNA对ABC转运蛋白表达的调节影响。通过分析当前的文献，本综述发现了一个明显的差距：缺乏对特定miRNA如何调节癌细胞中ABC转运蛋白的表达和活性从而导致阿霉素耐药性的全面了解。我们系统地研究了关于miRNA与ABC转运蛋白之间相互作用的最新发现，对利用miRNA调节来克服耐药性的潜在治疗策略进行了详细评估。最终，本综述强调了将miRNA研究纳入现有治疗框架以提高阿霉素在癌症治疗中疗效的重要性。
