Sun Mingli, Wang Xuanhao, Wang Yuqi, Meng Yuqian, Gao Da, Li Chiye, Chen Ruimin, Huang Kaikai, Shi Junhui
School of Science, Zhejiang University of Science and Technology, Hangzhou 310023, China.
Zhejiang Lab, Hangzhou 311100, China.
Biomed Opt Express. 2024 Nov 19;15(12):6864-6876. doi: 10.1364/BOE.540392. eCollection 2024 Dec 1.
Photoacoustic computed tomography (PACT) has evoked extensive interest for applications in preclinical and clinical research. However, the current systems suffer from the limited view provided by detection setups, thus impeding the sufficient acquisition of intricate tissue structures. Here, we propose an approach to enable fast 3D full-view imaging. A hemispherical ultrasonic transducer array combined with a planar acoustic reflector serves as the ultrasonic detection device in the PACT system. The planar acoustic reflector can create a mirrored virtual transducer array, and the detection view range can be enlarged to cover approximately 3.7 steradians in our detection setup. To verify the effectiveness of our proposed configuration, we present the imaging results of a hair phantom, an in vivo zebrafish larva, and a leaf skeleton phantom. Furthermore, the real-time dynamic imaging capacity of this system is demonstrated by observing the movement of zebrafish within 2 s. This strategy holds great potential for both preclinical and clinical research by providing more detailed and comprehensive images of biological tissues.
光声计算机断层扫描（PACT）在临床前和临床研究中的应用引起了广泛关注。然而，当前系统存在检测设置提供的视野有限的问题，从而妨碍了对复杂组织结构的充分采集。在此，我们提出一种实现快速三维全视野成像的方法。在PACT系统中，一个半球形超声换能器阵列与一个平面声反射器相结合，用作超声检测设备。平面声反射器可以创建一个镜像虚拟换能器阵列，在我们的检测设置中，检测视野范围可以扩大到覆盖约3.7球面度。为了验证我们提出的配置的有效性，我们展示了毛发模型、活体斑马鱼幼虫和叶片骨架模型的成像结果。此外，通过在2秒内观察斑马鱼的运动，证明了该系统的实时动态成像能力。通过提供更详细和全面的生物组织图像，该策略在临床前和临床研究中都具有巨大潜力。
