Wan Yantong, Zhou Jieshu, Li Hao
Department of Anesthesiology, West China Second University Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, People's Republic of China.
J Pain Res. 2024 Dec 11;17:4199-4212. doi: 10.2147/JPR.S490459. eCollection 2024.
Mechanosensitive Piezo channels are ion channels activated by mechanical stimuli, playing a crucial role in mechanotransduction processes and mechanical hypersensitivity. When these channels are subjected to mechanical loading, membrane currents rise instantaneously, depolarizing and activating voltage-gated calcium channels. This results in an increase in intracellular Ca, which contributes to heightened sensitivity to mechanical stimuli. This review delves into the characteristics and mechanisms of Piezo channels in chronic pain.
The findings suggest that Piezo channels are integral to the occurrence and development of chronic pain, including neuropathic pain, visceral pain, musculoskeletal pain, headache or orofacial pain, and inflammatory pain. Piezo channels significantly impact pain perception and transmission. These channels' critical involvement in various pain types highlights their potential as promising targets for chronic pain therapy.
This review discusses the role of Piezo channels in chronic pain. By understanding these pain mechanisms, new therapeutic strategies can be developed to alleviate chronic pain, offering hope for patients suffering from these debilitating conditions.
机械敏感的Piezo通道是由机械刺激激活的离子通道，在机械转导过程和机械超敏反应中起关键作用。当这些通道受到机械负荷时，膜电流瞬间上升，使电压门控钙通道去极化并激活。这导致细胞内钙离子增加，从而导致对机械刺激的敏感性增强。本综述深入探讨了Piezo通道在慢性疼痛中的特征和机制。
研究结果表明，Piezo通道对于慢性疼痛的发生和发展不可或缺，包括神经性疼痛、内脏疼痛、肌肉骨骼疼痛、头痛或口面部疼痛以及炎性疼痛。Piezo通道对疼痛感知和传递有显著影响。这些通道在各种疼痛类型中的关键作用凸显了它们作为慢性疼痛治疗潜在靶点的可能性。
本综述讨论了Piezo通道在慢性疼痛中的作用。通过了解这些疼痛机制，可以开发新的治疗策略来缓解慢性疼痛，为患有这些使人衰弱病症的患者带来希望。
