神经发育问题之间以及与攻击行为、抑郁、焦虑和物质使用之间的家族性共同聚集和共享家族性。

Familial co-aggregation and shared familiality among neurodevelopmental problems and with aggressive behavior, depression, anxiety, and substance use.

作者信息

Vos Melissa, Wang Rujia, Rommelse Nanda N J, Snieder Harold, Larsson Henrik, Hartman Catharina A

机构信息

Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Psychol Med. 2024 Dec 16:1-13. doi: 10.1017/S003329172400309X.

DOI:10.1017/S003329172400309X

PMID:39679547

Abstract

OBJECTIVE

To refine the knowledge on familial transmission, we examined the (shared) familial components among neurodevelopmental problems (i.e. two attention-deficit/hyperactivity-impulsivity disorder [ADHD] and six autism spectrum disorder [ASD] subdomains) and with aggressive behavior, depression, anxiety, and substance use.

METHODS

Data were obtained from a cross-sectional study encompassing 37 688 participants across three generations from the general population. ADHD subdomains, ASD subdomains, aggressive behavior, depression, anxiety, and substance use were assessed. To evaluate familial (co-)aggregation, recurrence risk ratios () were estimated using Cox proportional hazards models. The (shared) familiality (), which is closely related to (shared) heritability, was assessed using residual maximum likelihood-based variance decomposition methods. All analyses were adjusted for sex, age, and age.

RESULTS

The familial aggregation and familiality of neurodevelopmental problems were moderate ( = 2.40-4.04; = 0.22-0.39). The familial co-aggregation and shared familiality among neurodevelopmental problems ( = 1.39-2.56; = 0.52-0.94), and with aggressive behavior ( = 1.79-2.56; = 0.60-0.78), depression ( = 1.45-2.29; = 0.43-0.76), and anxiety ( = 1.44-2.31; = 0.62-0.84) were substantial. The familial co-aggregation and shared familiality between all neurodevelopmental problems and all types of substance use were weak ( = 0.53-1.57; = -0.06-0.35).

CONCLUSIONS

Neurodevelopmental problems belonging to the same disorder were more akin than cross-disorder problems. That said, there is a clear (shared) familial component to neurodevelopmental problems, in part shared with other psychiatric problems (except for substance use). This suggests that neurodevelopmental disorders, disruptive behavior disorders, and internalizing disorders share genetic and environmental risk factors.

摘要

目的

为完善对家族遗传的认识，我们研究了神经发育问题（即两种注意力缺陷/多动冲动障碍[ADHD]和六种自闭症谱系障碍[ASD]子领域）之间以及与攻击行为、抑郁、焦虑和物质使用之间的（共同）家族因素。

方法

数据来自一项横断面研究，涵盖了来自普通人群的三代37688名参与者。对ADHD子领域、ASD子领域、攻击行为、抑郁、焦虑和物质使用进行了评估。为评估家族性（共同）聚集情况，使用Cox比例风险模型估计复发风险比（）。使用基于残差最大似然的方差分解方法评估与（共同）遗传力密切相关的（共同）家族性（）。所有分析均针对性别、年龄进行了调整。

结果

神经发育问题的家族聚集性和家族性为中等水平（=2.40 - 4.04；=0.22 - 0.39）。神经发育问题之间（=1.39 - 2.56；=0.52 - 0.94）以及与攻击行为（=1.79 - 2.56；=0.60 - 0.78）、抑郁（=1.45 - 2.29；=0.43 - 0.76）和焦虑（=1.44 - 2.31；=0.62 - 0.84）之间的家族共同聚集性和共同家族性较强。所有神经发育问题与所有类型物质使用之间的家族共同聚集性和共同家族性较弱（=0.53 - 1.57；= - 0.06 - 0.35）。