Li Xiaoyun, Xu Yue, Zhou Zijun, Tang Mingliang, Cui Jinjia, Han Wenjing, Li Jingyi, Dai Jing, Ren Xiaoyi, Jiang Huihui, Yu Yanzhen, Liu Qinghua, Tang Hongmei, Xiao Miao
Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science, Suzhou Medical College, Soochow University, Suzhou 215000, China.
Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing 211166, China.
Biomacromolecules. 2025 Jan 13;26(1):405-414. doi: 10.1021/acs.biomac.4c01211. Epub 2024 Dec 16.
Type I collagen, a crucial component maintaining the structural integrity and physiological function of various tissues, is widely regarded as one of the most suitable biomaterials for healthcare applications. In this study, shad scales, used for treating ulcers, scalds, and burns in traditional Chinese medicine, were exploited for type I collagen extraction. After self-assembly into hydrogels, the extracted collagen was subsequently freeze-dried to form collagen sponges. The collagen sponge promoted rapid hemostasis, neovascularization, and immune regulation. Additionally, it accelerated the formation of granulation tissue, re-epithelialization, and collagen remodeling at the wound site in full-thickness skin wound rat models. Consequently, the shad scale collagen sponge holds great promise for the treatment of chronic wounds and skin regeneration. Notably, the shad was sourced from sustainably recirculating aquaculture systems (RAS) farms that adhere to the Traceable Management of Animal Products Safety, ensuring that the derived collagen possesses potential in the medical apparatus market.
I型胶原蛋白是维持各种组织结构完整性和生理功能的关键成分，被广泛认为是医疗保健应用中最合适的生物材料之一。在本研究中，用于治疗溃疡、烫伤和烧伤的中药鲥鱼鳞被用于提取I型胶原蛋白。提取的胶原蛋白自组装成水凝胶后，随后进行冷冻干燥以形成胶原海绵。胶原海绵促进快速止血、新血管形成和免疫调节。此外，它加速了全层皮肤伤口大鼠模型伤口部位肉芽组织的形成、再上皮化和胶原重塑。因此，鲥鱼鳞胶原海绵在慢性伤口治疗和皮肤再生方面具有巨大潜力。值得注意的是，鲥鱼来自可持续循环水产养殖系统（RAS）农场，这些农场遵守动物产品安全的可追溯管理，确保衍生的胶原蛋白在医疗器械市场具有潜力。
