Zechman F W, Muza S R, Davenport P W, Wiley R L, Shelton R
J Appl Physiol (1985). 1985 Jan;58(1):236-43. doi: 10.1152/jappl.1985.58.1.236.
The purpose of this investigation was to measure changes in transdiaphragmatic pressure (Pdi) developed during graded elastic (E) and resistive (R) loaded breaths and to correlate the emergence of such changes with the load-dependent alterations in latency for detection (Tdet). Five healthy adults were studied using three protocols, i.e., graded E, graded R, and graded R in the presence of elevated background R. In each protocol, loads were added for single inspirations, 10 times in random order and separated by three to five unloaded breaths. Subjects pressed a signal marker as soon as loads were detected. Inspiratory flow (VI), inspired volume (VI), mouth pressure, and Pdi of loaded breaths and the preceding unloaded breaths were recorded and computer averaged. Patterns of VI and VI were not altered prior to detection of the smallest added E and R loads but decreased with the higher loads. Group mean patterns of Pdi showed graded increases during loaded breaths. Augmentation of Pdi preceded Tdet and occurred earlier as Tdet decreased with graded E and R loads. Elevating the background R delayed both Tdet of added R and the augmentation of Pdi. Results are consistent with the hypothesis that load-induced changes in diaphragmatic tension may play a sensory role in detection of inspiratory loads.
本研究的目的是测量在分级弹性（E）负荷和阻力（R）负荷呼吸过程中产生的跨膈压（Pdi）变化，并将这些变化的出现与负荷依赖性检测潜伏期（Tdet）的改变相关联。使用三种方案对五名健康成年人进行了研究，即分级E、分级R以及在背景R升高的情况下进行分级R。在每个方案中，对单次吸气添加负荷，以随机顺序进行10次，中间间隔三到五次无负荷呼吸。受试者一旦检测到负荷就按下信号标记。记录负荷呼吸和之前无负荷呼吸的吸气流量（VI）、吸入容积（VI）、口腔压力和Pdi，并进行计算机平均。在检测到最小的添加E和R负荷之前，VI和VI的模式没有改变，但随着负荷增加而降低。Pdi的组平均模式在负荷呼吸期间呈分级增加。Pdi的增强先于Tdet，并且随着分级E和R负荷导致Tdet降低而更早出现。提高背景R会延迟添加R的Tdet和Pdi的增强。结果与以下假设一致，即负荷引起的膈肌张力变化可能在吸气负荷检测中起感觉作用。
