Raposo Pereira Filipa, Chaumon Maximilien, Dubois Bruno, Bakardjian Hovagim, Bahrami Mahsa, Habert Marie-Odile, Andrade Katia, Younsi Nadjia, La Corte Valentina, George Nathalie
Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, U 1127, CNRS, UMR 7225, AP-HP, CENIR, Centre MEG-EEG, Hôpital de La Pitié-Salpêtrière, 47 Boulevard de L'Hôpital, 75013, Paris, France.
Department of Neurology, Institute of Memory and Alzheimer's Disease (IM2A), Pitié-Salpêtrière University Hospital, AP-HP, Paris, France.
J Neurol. 2024 Dec 16;272(1):70. doi: 10.1007/s00415-024-12834-y.
Episodic memory (EM) alterations are a hallmark of Alzheimer's disease (AD). We assessed EM longitudinally in cognitively normal elders at-risk for AD (with subjective memory complaints), as a function of amyloid-β (Aβ) burden, neurodegeneration (N), and progression to prodromal AD. We stratified 264 INSIGHT-preAD study subjects in controls (Aβ-/N-), stable/N- or N + (Aβ +), and progressors/N- or N + (Aβ +) groups (progressors were included only until AD-diagnosis). We used linear mixed-effect models with Aβ and N status, or progression to AD as factors, to analyze behavioral performance in an old/new word-recognition task based on the free and cued selective reminding test (FCSRT). The controls and stable/N- groups showed near-ceiling accuracy and RT improvement across follow-up. The stable/N + group showed accuracy reduction and no RT improvement, i.e., Aβ + /N + cumulative effect. The progressors showed a marked performance decline. EM alterations may constitute early preclinical markers of progression to prodromal AD, while individuals are cognitively normal according to neuropsychological standards.
情景记忆（EM）改变是阿尔茨海默病（AD）的一个标志。我们对有AD风险（有主观记忆障碍）的认知正常老年人的情景记忆进行了纵向评估，作为淀粉样β蛋白（Aβ）负荷、神经退行性变（N）以及向前驱AD进展的函数。我们将264名INSIGHT-preAD研究对象分为对照组（Aβ-/N-）、稳定/N-组或N+（Aβ+）组，以及进展组/N-或N+（Aβ+）组（进展组仅纳入至AD诊断）。我们使用以Aβ和N状态或向AD进展为因素的线性混合效应模型，来分析基于自由和提示性选择性回忆测试（FCSRT）的新旧单词识别任务中的行为表现。对照组和稳定/N-组在随访期间表现出接近上限的准确率和反应时改善。稳定/N+组表现出准确率降低且反应时无改善，即Aβ+/N+累积效应。进展组表现出明显的行为表现下降。情景记忆改变可能构成向前驱AD进展的早期临床前标志物，而此时个体根据神经心理学标准认知正常。
