Choi Jungyoon, Wen Wanqing, Jia Guochong, Tao Ran, Long Jirong, Shu Xiao-Ou, Zheng Wei
Division of Oncology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Gyeonggi-Do, Korea.
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
J Cardiovasc Transl Res. 2025 Apr;18(2):331-340. doi: 10.1007/s12265-024-10578-8. Epub 2024 Dec 16.
Circulating lipids play a crucial role in the development of coronary artery disease (CAD). However, it is unclear whether the genetic susceptibility to hyperlipidemia may interact with lifestyle factors in CAD risk. Using UK Biobank data from 328,606 participants, we evaluated combined effects of genetic susceptibility to hyperlipidemia and lifestyle factors with risk of CAD. We found that both blood lipid-related polygenic score (PGS) and healthy lifestyle score (HLS) are independently associated with CAD risk, and individuals with the highest-risk lipid-related PGS and the least healthy HLS had the highest CAD risk. This association was stronger in younger (< 60 years, hazard ratio: 4.46, 95% confidence interval: 3.44-5.78) than older adults (2.54, 2.13-3.03). Our study suggests that individuals, particularly younger adults, with higher-risk PGSs of blood lipid traits would benefit more substantially by adherence to a healthy lifestyle than those with lower PGSs.
循环脂质在冠状动脉疾病（CAD）的发展中起着至关重要的作用。然而，尚不清楚高脂血症的遗传易感性是否可能与CAD风险中的生活方式因素相互作用。利用来自328,606名参与者的英国生物银行数据，我们评估了高脂血症的遗传易感性和生活方式因素对CAD风险的综合影响。我们发现，血脂相关多基因评分（PGS）和健康生活方式评分（HLS）均与CAD风险独立相关，并且血脂相关PGS风险最高且HLS最不健康的个体CAD风险最高。这种关联在年轻人（<60岁，风险比：4.46，95%置信区间：3.44 - 5.78）中比老年人（2.54，2.13 - 3.03）更强。我们的研究表明，与PGS较低的个体相比，具有较高血脂性状风险PGS的个体，尤其是年轻人，坚持健康的生活方式将获益更多。
