Chatterjee Sohini, Mohanta Abhishek, De Arnab, Mukherjee Ashmita, Hazra Ahana, Niloy Pratik Paul, Tudu Mousumi, Chattopadhyay Krishnananda, Samanta Amalesh
Division of Microbiology & Pharmaceutical Biotechnology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Department of Pharmaceutics, Bharat Technology, Uluberia, Howrah, West Bengal 711316, India.
Int J Biol Macromol. 2025 Feb;288:138708. doi: 10.1016/j.ijbiomac.2024.138708. Epub 2024 Dec 14.
Antimicrobial buccal hydrogel made of polymers have gained tremendous utilisation in biomedical field. Dual drug loaded, porous materials are important areas of research for medical and pharmaceutical industries. In this regard, a series of hydrogels (F1, F2, F3) were prepared with gum odina and carbopol 940 in aqueous solution with calcium chloride as the cross linker and glycerol as plasticizer by ionotropic gelation method. The buccal hydrogel was evaluated for thermal stability (TGA/DSC) revealing them to be thermally stable. The SEM and AFM studies of the optimized formulation (F2) exhibits cracks and porous structure. It also depicted good injectability and self-healing. The XRD result displayed amorphous nature of the formulation (F2) making them soluble in buccal fluids. The chemical nature and interactions were analysed by FTIR study. The release profile portrayed controlled release patterns for amoxicillin trihydrate and fluconazole. Appreciable mucoadhesion time (6 ± 0.7 h) and strength (12.03 ± 0.45 g) was observed in case of F2. The optimized formulation F2 displayed good antifungal and antibacterial properties. Thus, it is concluded that the hydrogel formed were mucoadhesive and highly potent to carry drug molecules for controlled release in the buccal mucosa to treat several periodontal infections.
由聚合物制成的抗菌口腔水凝胶在生物医学领域得到了广泛应用。双载药多孔材料是医疗和制药行业重要的研究领域。在这方面，通过离子凝胶法，以奥蒂纳胶和卡波姆940为原料，氯化钙为交联剂，甘油为增塑剂，在水溶液中制备了一系列水凝胶（F1、F2、F3）。对口腔水凝胶进行热稳定性评估（TGA/DSC），结果表明它们具有热稳定性。对优化配方（F2）进行扫描电子显微镜（SEM）和原子力显微镜（AFM）研究，结果显示其具有裂缝和多孔结构。它还表现出良好的可注射性和自愈性。X射线衍射（XRD）结果显示配方（F2）具有无定形性质，使其可溶于口腔液体。通过傅里叶变换红外光谱（FTIR）研究分析了其化学性质和相互作用。释放曲线显示三水合阿莫西林和氟康唑呈现控释模式。在F2的情况下，观察到了可观的粘膜粘附时间（6±0.7小时）和强度（12.03±0.45克）。优化后的配方F2表现出良好的抗真菌和抗菌性能。因此，可以得出结论，所形成的水凝胶具有粘膜粘附性，并且在口腔粘膜中携带药物分子进行控释以治疗多种牙周感染方面具有高效性。
