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加拿大监狱针头交换项目预防丙型肝炎及注射相关感染的成本效益分析。

Cost-benefit analysis of Canada's Prison Needle Exchange Program for the prevention of hepatitis C and injection-related infections.

作者信息

Houdroge Farah, Kronfli Nadine, Stoové Mark, Scott Nick

机构信息

Disease Elimination Program (Houdroge, Stoové, Scott), Burnet Institute, Melbourne, Australia; Division of Infectious Diseases and Chronic Viral Illness Service (Kronfli), Department of Medicine, McGill University Health Centre; Centre for Outcomes Research and Evaluation (Kronfli), Research Institute of the McGill University Health Centre, Montréal, Que.; School of Public Health and Preventive Medicine (Stoové, Scott), Monash University, Melbourne, Australia.

出版信息

CMAJ. 2024 Dec 15;196(43):E1401-E1412. doi: 10.1503/cmaj.240648.

Abstract

BACKGROUND

Needle exchange programs are effective public health interventions that reduce blood-borne infections, including hepatitis C, and injection-related infections. We sought to assess the return on investment of existing Prison Needle Exchange Programs (PNEPs) in Canadian federal prisons and their expansion to all 43 institutions.

METHODS

We developed a stochastic compartmental model that estimated hepatitis C and injection-related infections under different PNEP scenarios in Canadian federal prisons. Scenarios projected for 2018-2030 were no PNEP, status quo (actual PNEP implementation 2018-2022, with coverage maintained to 2030), and PNEP scale-up (coverage among people who inject drugs in prison increasing over 2025-2030 to reach 50% by 2030). We calculated the benefit-cost ratio as benefits from health care savings, divided by PNEP costs.

RESULTS

By 2019, PNEPs were implemented in 9 of 43 federal prisons, with uptake reaching 10% of people who injected drugs in prison in 2022. Compared with no PNEP, this was estimated to cost Can$0.45 (uncertainty interval [UI] $0.32 to $0.98) million and avert 37 (UI 25 to 52) hepatitis C and 8 (UI -1 to 16) injection-related infections over 2018-2030, with a benefit-cost ratio of 1.9 (UI 0.56-3.0). Compared with the status quo, the PNEP scale-up scenario cost an additional $2.7 (UI $1.8 to $7.0) million and prevented 224 (UI 218 to 231) hepatitis C and 77 (UI 74 to 80) injection-related infections, with a benefit-cost ratio of 2.0 (UI 0.57 to 3.3).

INTERPRETATION

Every dollar invested in the current PNEP or its expansion is estimated to save $2 in hepatitis C and injection-related infection treatment costs. This return on investment strongly supports ongoing maintenance and scale-up of the PNEP in Canada from an economic perspective.

摘要

背景

针头交换项目是有效的公共卫生干预措施,可减少包括丙型肝炎在内的血源性感染以及与注射相关的感染。我们试图评估加拿大联邦监狱现有监狱针头交换项目(PNEP)的投资回报率以及将其扩展至所有43所监狱的情况。

方法

我们开发了一个随机 compartmental 模型,用于估计加拿大联邦监狱在不同PNEP情景下的丙型肝炎和与注射相关的感染情况。预测的2018 - 2030年情景包括无PNEP、现状(2018 - 2022年实际实施PNEP,并维持覆盖率至2030年)以及PNEP扩大规模(2025 - 2030年监狱中注射毒品者的覆盖率增加,到2030年达到50%)。我们计算效益成本比,即医疗保健节省带来的效益除以PNEP成本。

结果

到2019年,43所联邦监狱中有9所实施了PNEP,2022年监狱中注射毒品者的参与率达到10%。与无PNEP相比,预计在2018 - 2030年期间,这将花费45万加元(不确定区间[UI]为32万至98万加元),避免37例(UI为25至52例)丙型肝炎和8例(UI为 - 1至16例)与注射相关的感染,效益成本比为1.9(UI为0.56 - 3.0)。与现状相比,PNEP扩大规模情景额外花费270万加元(UI为180万至700万加元),预防224例(UI为218至231例)丙型肝炎和77例(UI为74至80例)与注射相关的感染,效益成本比为2.0(UI为0.57至3.3)。

解读

预计在当前的PNEP或其扩展项目上每投入1加元,可在丙型肝炎和与注射相关的感染治疗成本上节省2加元。从经济角度来看,这种投资回报率有力地支持了加拿大持续维持和扩大PNEP。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b91/11649329/307e6f0ea9ce/196e1401f1.jpg

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