Houdroge Farah, Kronfli Nadine, Stoové Mark, Scott Nick
Disease Elimination Program (Houdroge, Stoové, Scott), Burnet Institute, Melbourne, Australia; Division of Infectious Diseases and Chronic Viral Illness Service (Kronfli), Department of Medicine, McGill University Health Centre; Centre for Outcomes Research and Evaluation (Kronfli), Research Institute of the McGill University Health Centre, Montréal, Que.; School of Public Health and Preventive Medicine (Stoové, Scott), Monash University, Melbourne, Australia.
CMAJ. 2024 Dec 15;196(43):E1401-E1412. doi: 10.1503/cmaj.240648.
Needle exchange programs are effective public health interventions that reduce blood-borne infections, including hepatitis C, and injection-related infections. We sought to assess the return on investment of existing Prison Needle Exchange Programs (PNEPs) in Canadian federal prisons and their expansion to all 43 institutions.
We developed a stochastic compartmental model that estimated hepatitis C and injection-related infections under different PNEP scenarios in Canadian federal prisons. Scenarios projected for 2018-2030 were no PNEP, status quo (actual PNEP implementation 2018-2022, with coverage maintained to 2030), and PNEP scale-up (coverage among people who inject drugs in prison increasing over 2025-2030 to reach 50% by 2030). We calculated the benefit-cost ratio as benefits from health care savings, divided by PNEP costs.
By 2019, PNEPs were implemented in 9 of 43 federal prisons, with uptake reaching 10% of people who injected drugs in prison in 2022. Compared with no PNEP, this was estimated to cost Can$0.45 (uncertainty interval [UI] $0.32 to $0.98) million and avert 37 (UI 25 to 52) hepatitis C and 8 (UI -1 to 16) injection-related infections over 2018-2030, with a benefit-cost ratio of 1.9 (UI 0.56-3.0). Compared with the status quo, the PNEP scale-up scenario cost an additional $2.7 (UI $1.8 to $7.0) million and prevented 224 (UI 218 to 231) hepatitis C and 77 (UI 74 to 80) injection-related infections, with a benefit-cost ratio of 2.0 (UI 0.57 to 3.3).
Every dollar invested in the current PNEP or its expansion is estimated to save $2 in hepatitis C and injection-related infection treatment costs. This return on investment strongly supports ongoing maintenance and scale-up of the PNEP in Canada from an economic perspective.
针头交换项目是有效的公共卫生干预措施,可减少包括丙型肝炎在内的血源性感染以及与注射相关的感染。我们试图评估加拿大联邦监狱现有监狱针头交换项目(PNEP)的投资回报率以及将其扩展至所有43所监狱的情况。
我们开发了一个随机 compartmental 模型,用于估计加拿大联邦监狱在不同PNEP情景下的丙型肝炎和与注射相关的感染情况。预测的2018 - 2030年情景包括无PNEP、现状(2018 - 2022年实际实施PNEP,并维持覆盖率至2030年)以及PNEP扩大规模(2025 - 2030年监狱中注射毒品者的覆盖率增加,到2030年达到50%)。我们计算效益成本比,即医疗保健节省带来的效益除以PNEP成本。
到2019年,43所联邦监狱中有9所实施了PNEP,2022年监狱中注射毒品者的参与率达到10%。与无PNEP相比,预计在2018 - 2030年期间,这将花费45万加元(不确定区间[UI]为32万至98万加元),避免37例(UI为25至52例)丙型肝炎和8例(UI为 - 1至16例)与注射相关的感染,效益成本比为1.9(UI为0.56 - 3.0)。与现状相比,PNEP扩大规模情景额外花费270万加元(UI为180万至700万加元),预防224例(UI为218至231例)丙型肝炎和77例(UI为74至80例)与注射相关的感染,效益成本比为2.0(UI为0.57至3.3)。
预计在当前的PNEP或其扩展项目上每投入1加元,可在丙型肝炎和与注射相关的感染治疗成本上节省2加元。从经济角度来看,这种投资回报率有力地支持了加拿大持续维持和扩大PNEP。