Ehsani Ala, Falakian Setareh, Ehsani Amirhoushang, Hamzelou Shahin, Balighi Kamran, Razavi Zahra, Aryanian Zeinab, Khayyat Azadeh, Hatami Parvaneh
Medical Students, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
J Cosmet Dermatol. 2025 Feb;24(2):e16733. doi: 10.1111/jocd.16733. Epub 2024 Dec 16.
The skin is the largest organ system with many important clinical functions. Due to the increase in demand for cosmetic procedures and consequently the increase in complications from filler injections, this research aims to review the hospitalization cases involving filler complications.
This study retrospectively and cross-sectionally reviews patient records hospitalized between the years 2016 to 2020, focusing on demographics (age, gender, residence), type of filler, type of complications, onset and duration of complications, duration of hospital stay, the person who administered the injection, and treatment outcomes. The goal is to understand the complications, prognosis, and potential risk factors.
A total of 58 patients were hospitalized due to complications arising from filler injections between 2016 and 2020. The average age of patients was approximately 37.79 years, ranging from 15 to 62 years old. A majority, 94.8%, were female and 62.1% were married. The most common filler used was hyaluronic acid, accounting for 81% of cases. Complications included cellulitis in 41.4% of cases, abscesses in 29.3%, granulomatous inflammation in 19%, and necrosis in 10.3%. The shortest hospital stay was 1 day and the longest was 9 days, with an average stay of approximately 2.33 days. In 65.5% of the cases, the injections were administered by medical professionals, and in 34.5%, by individuals without medical credentials. Married individuals generally sought hospital care later than others. Severe complications were more likely to occur when injections were administered by nonprofessionals. The time to seek medical attention was shorter for severe complications than for moderate ones. There were no deaths among the cases studied.
The study highlights the variation in complication severity associated with filler injections performed by nonmedical personnel, emphasizing the importance of prohibiting such practices. Educating patients about the early signs of complications can significantly reduce severe outcomes and decrease antibiotic resistance.
皮肤是最大的器官系统，具有许多重要的临床功能。由于美容手术需求的增加以及由此导致的填充剂注射并发症的增多，本研究旨在回顾涉及填充剂并发症的住院病例。
本研究对2016年至2020年间住院患者的病历进行回顾性横断面研究，重点关注人口统计学特征（年龄、性别、居住地）、填充剂类型、并发症类型、并发症的发生和持续时间、住院时间、注射实施者以及治疗结果。目的是了解并发症、预后及潜在风险因素。
2016年至2020年间，共有58例患者因填充剂注射并发症住院。患者的平均年龄约为37.79岁，年龄范围为15至62岁。大多数患者（94.8%）为女性，62.1%已婚。最常用的填充剂是透明质酸，占病例的81%。并发症包括蜂窝织炎（41.4%）、脓肿（29.3%）、肉芽肿性炎症（19%）和坏死（10.3%）。最短住院时间为1天，最长为9天，平均住院时间约为2.33天。65.5%的病例由医疗专业人员进行注射，34.5%由无医疗资质的个人进行注射。已婚者通常比其他人寻求医院治疗的时间晚。非专业人员进行注射时，严重并发症更易发生。严重并发症患者寻求医疗救治的时间比中度并发症患者短。研究病例中无死亡病例。
该研究突出了非医务人员进行填充剂注射相关并发症严重程度的差异，强调了禁止此类行为的重要性。对患者进行并发症早期症状的教育可显著降低严重后果并减少抗生素耐药性。
