Lee Soo-Keun, Kim So Min, Cho Sang Hyun, Lee Jeong Deuk, Kim Hei Sung
Mein Skin Clinic , Seoul , Republic of Korea.
J Cosmet Laser Ther. 2015 Apr;17(2):102-8. doi: 10.3109/14764172.2014.968584. Epub 2014 Oct 16.
Filler injection is a minimally invasive procedure widely used for soft tissue augmentation. Although the safety profile is favorable, adverse events can occur, especially after illegal filler injection.
The authors present memorable cases of filler complications and review their clinico-pathological features and treatment strategies.
This is a retrospective, single-center case series. The authors identified eight patients with significant complications following filler injection. A medical record review was performed for clinical history, histopathological studies, and treatment.
Six female and two male subjects presented with significant filler complications. The time interval between filler injection and the development of a complication varied greatly among cases (immediately afterwards to 14 years following filler injection). Four of the patients received illegal filler injection where the injected material was either unknown (25%) or was told as paraffin (12.5%) or Vaseline(®) (12.5%). Hyaluronic acid fillers were used in two patients (25%) and the rest were injected with porcine atelocollagen (12.5%) and polyacrylamide hydrogel (12.5%). The complications were classified as an allergic reaction (25%), filler material migration (12.5%), injection necrosis + embolism (25%), and foreign body granuloma (37.5%), based on their clinico-pathological features and were treated accordingly.
Adverse effects are not uncommon following filler injection. Physicians should be aware of the potential side effects, recognize their presentations, and understand how to manage them.
填充剂注射是一种广泛用于软组织填充的微创手术。尽管安全性良好，但仍可能发生不良事件，尤其是在非法注射填充剂之后。
作者介绍了填充剂并发症的典型病例，并回顾了其临床病理特征及治疗策略。
这是一项回顾性单中心病例系列研究。作者确定了8例填充剂注射后出现严重并发症的患者。对其临床病史、组织病理学研究及治疗情况进行了病历审查。
6名女性和2名男性出现了严重的填充剂并发症。填充剂注射与并发症发生之间的时间间隔在不同病例中差异很大（注射后立即出现至注射后14年）。4例患者接受了非法填充剂注射，注射材料未知（25%），被告知为石蜡（12.5%）或凡士林（12.5%）。2例患者使用了透明质酸填充剂（25%），其余患者分别注射了猪脱细胞胶原蛋白（12.5%）和聚丙烯酰胺水凝胶（12.5%）。根据临床病理特征，并发症分为过敏反应（25%）、填充材料迁移（12.5%）、注射坏死+栓塞（25%）和异物肉芽肿（37.5%），并据此进行了相应治疗。
填充剂注射后不良反应并不罕见。医生应意识到潜在的副作用，识别其表现，并了解如何进行处理。
