Luck P, Wakeling A
Br Med J. 1980 Oct 4;281(6245):906-8. doi: 10.1136/bmj.281.6245.906.
The changes in peripheral (hand) blood flow that occurred when deep body temperature was raised were measured in 13 patients with anorexia nervosa and 13 control subjects. The relation between blood flow and core temperature was shifted to the left in the patients with anorexia, with the onset of vasodilatation occurring at lower core and mean skin temperatures: no significant differences in the slopes of the responses were evident. The onset of thermal sweating occurred at lower core and mean skin temperatures in the patients with anorexia than in the controls. After ingestion of a high-energy liquid meal core temperature increased in the patients, and this was accompanied by a significant rise in peripheral blood flow in most cases. A similar meal in the normal subjects was followed by either no change in core temperature or a slight fall, and no consistent change in peripheral blood flow. These findings suggest that the lowering of thresholds for thermoregulatory sweating and vasodilatation may be a contributory factor to the abnormally low core temperature of patients with anorexia and may also explain some of their common complaints relating to feelings of warmth in the hands and feet after meals.
对13名神经性厌食症患者和13名对照受试者进行了测量，以观察深部体温升高时外周（手部）血流的变化。在神经性厌食症患者中，血流与核心体温之间的关系向左偏移，血管舒张在较低的核心体温和平均皮肤温度时就开始出现：反应斜率无显著差异。神经性厌食症患者热出汗的起始核心体温和平均皮肤温度低于对照组。摄入高能流食后，患者的核心体温升高，多数情况下外周血流显著增加。正常受试者摄入类似食物后，核心体温无变化或略有下降，外周血流无一致变化。这些发现表明，体温调节性出汗和血管舒张阈值降低可能是神经性厌食症患者核心体温异常低的一个促成因素，也可能解释了他们饭后手脚有温热感的一些常见主诉。
