Bilgiç Bengü, Tarhan Duygu, Or Mehmet Erman
Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul 34320, Turkey.
Department of Biophysics, School of Medicine, Bahcesehir University, Goztepe, Istanbul 34734, Turkey.
Animals (Basel). 2024 Nov 25;14(23):3390. doi: 10.3390/ani14233390.
The prognostic and diagnostic role of some trace elements in heart diseases has been demonstrated. In this study, the effects of min. 30-day and min. 120-day treatment with pimobendan, enalapril, and furosemide, as monotherapy and in combination, on serum trace element levels in dogs with heart failure were evaluated. A total of 107 dogs were treated with pimobendan or enalapril as monotherapy and pimobendan + enalapril (PE), enalapril + furosemide (EF), or pimobendan + enalapril + furosemide (PEF) as combination therapy for a min. of 30 and 120 days. Serum copper (Cu), zinc (Zn), iron (Fe), cobalt (Co), magnesium (Mg), manganese (Mn), selenium (Se), and chromium (Cr) were measured by an inductive coupled plasma optical emission spectroscopy device. Mean serum Mg in dogs treated with pimobendan for a min. of 120 days was significantly lower than that for a min. of 30 days ( < 0.05). In dogs using the PEF combination, mean serum Fe was significantly higher in the min. 120-day treatment group than in the min. 30-day treatment group ( < 0.01). No significant difference was observed in mean serum Cu, Zn, Co, Mn, Se, or Cr between the treatment groups and the time periods ( > 0.05). The short- and long-term use of pimobendan, enalapril, furosemide, and their combinations may cause changes in mean serum Mg and Fe in dogs with heart failure.
一些微量元素在心脏病中的预后和诊断作用已得到证实。在本研究中，评估了匹莫苯丹、依那普利和呋塞米单独使用及联合使用至少30天和至少120天对心力衰竭犬血清微量元素水平的影响。共有107只犬接受了匹莫苯丹或依那普利单药治疗，以及匹莫苯丹+依那普利（PE）、依那普利+呋塞米（EF）或匹莫苯丹+依那普利+呋塞米（PEF）联合治疗，治疗时间至少为30天和120天。采用电感耦合等离子体发射光谱仪测定血清铜（Cu）、锌（Zn）、铁（Fe）、钴（Co）、镁（Mg）、锰（Mn）、硒（Se）和铬（Cr）。接受匹莫苯丹治疗至少120天的犬血清镁平均水平显著低于治疗至少30天的犬（<0.05）。在使用PEF联合治疗的犬中，120天治疗组的血清铁平均水平显著高于30天治疗组（<0.01）。治疗组和不同时间段之间的血清铜、锌、钴、锰、硒或铬平均水平未观察到显著差异（>0.05）。匹莫苯丹、依那普利、呋塞米及其联合药物的短期和长期使用可能会导致心力衰竭犬血清镁和铁的平均水平发生变化。
