Perfetti Simone, Guglielmini Carlo, Linta Nikolina, Diana Alessia
Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, Italy.
Department of Animal Medicine, Production and Health, University of Padua, 35020 Legnaro, Italy.
Animals (Basel). 2024 Dec 5;14(23):3521. doi: 10.3390/ani14233521.
Multidetector-row computed tomographic angiography (angio-CT) aims to achieve optimal opacification of the vascular compartment of interest. The distribution and quality of vascular opacification are influenced by patient-related factors, contrast medium (CM)-related factors, and scanner-related factors. This systematic review evaluates these factors and their effects on contrast enhancement. A comprehensive literature search was made in February 2024 across four online bibliographic databases (Web of Science, PubMed, Scopus, and CAB Abstract) in adherence with the PRISMA 2020 guidelines. After screening the 5990 unique published articles initially identified, 20 full-text original studies met the inclusion criteria for the final review. The amount of abdominal adipose tissue was found to significantly affect enhancement, which suggests the possibility of reducing the CM dose to minimize adverse effects or toxicity. The injection rate of the CM, rather than the injection duration, was identified as the most critical factor, with important clinical implications. For scanners with slower acquisition speeds or longer scan durations, maintaining a fixed CM injection duration may optimize vascular phase acquisition. In contrast, faster scanners benefit from bolus tracking, which allows for improved differentiation between vascular phases. Additionally, administering a saline flush post-CM injection enhances arterial opacification while reducing the necessary CM dose. This systematic review highlights essential factors influencing contrast enhancement in angio-CT for dogs and provides a foundation for future research aimed at optimizing imaging protocols in veterinary medicine.
多排螺旋计算机断层血管造影（血管CT）旨在实现目标血管腔的最佳强化。血管强化的分布和质量受患者相关因素、造影剂（CM）相关因素和扫描仪相关因素影响。本系统评价评估了这些因素及其对对比增强的影响。2024年2月，按照PRISMA 2020指南，在四个在线书目数据库（科学网、PubMed、Scopus和CAB文摘）中进行了全面的文献检索。在筛选最初确定的5990篇独特发表文章后，20项全文原始研究符合最终评价的纳入标准。发现腹部脂肪组织量显著影响强化，这提示有可能降低造影剂剂量以尽量减少不良反应或毒性。造影剂的注射速率而非注射持续时间被确定为最关键因素，具有重要临床意义。对于采集速度较慢或扫描持续时间较长的扫描仪，保持固定的造影剂注射持续时间可能优化血管期采集。相反，更快的扫描仪受益于团注追踪，这有助于改善血管期之间的区分。此外，在注射造影剂后给予生理盐水冲洗可增强动脉强化，同时减少所需的造影剂剂量。本系统评价强调了影响犬血管CT对比增强的重要因素，并为未来旨在优化兽医学成像方案的研究奠定了基础。
